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Amyloidosis in multiple myeloma or without apparent cause.
Arch Intern Med. 1984 Nov; 144(11):2158-60.AI

Abstract

Thirty-two patients with primary amyloidosis (AL) either due to multiple myeloma or without apparent cause were studied. The most common manifestations were carpal tunnel syndrome and nephrosis. Rectal biopsy specimens showed amyloid infiltrates in 65% (15 of 23) of the patients studied, but virtually all biopsies of normal skin were negative. lambda Light chains were present in 75% (21 of 28) of patients with a monoclonal gammopathy. The median survival time was 14 months after histologic diagnosis, following a median delay of seven months from the recognition of disease by a physician. An earlier diagnosis would have been possible in most of the patients if the initial findings of amyloidosis had been recognized and evaluated definitively. The prognosis remains poor, because effective therapy is not available.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6437354

Citation

Alexanian, R, et al. "Amyloidosis in Multiple Myeloma or Without Apparent Cause." Archives of Internal Medicine, vol. 144, no. 11, 1984, pp. 2158-60.
Alexanian R, Fraschini G, Smith L. Amyloidosis in multiple myeloma or without apparent cause. Arch Intern Med. 1984;144(11):2158-60.
Alexanian, R., Fraschini, G., & Smith, L. (1984). Amyloidosis in multiple myeloma or without apparent cause. Archives of Internal Medicine, 144(11), 2158-60.
Alexanian R, Fraschini G, Smith L. Amyloidosis in Multiple Myeloma or Without Apparent Cause. Arch Intern Med. 1984;144(11):2158-60. PubMed PMID: 6437354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amyloidosis in multiple myeloma or without apparent cause. AU - Alexanian,R, AU - Fraschini,G, AU - Smith,L, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 2158 EP - 60 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 144 IS - 11 N2 - Thirty-two patients with primary amyloidosis (AL) either due to multiple myeloma or without apparent cause were studied. The most common manifestations were carpal tunnel syndrome and nephrosis. Rectal biopsy specimens showed amyloid infiltrates in 65% (15 of 23) of the patients studied, but virtually all biopsies of normal skin were negative. lambda Light chains were present in 75% (21 of 28) of patients with a monoclonal gammopathy. The median survival time was 14 months after histologic diagnosis, following a median delay of seven months from the recognition of disease by a physician. An earlier diagnosis would have been possible in most of the patients if the initial findings of amyloidosis had been recognized and evaluated definitively. The prognosis remains poor, because effective therapy is not available. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/6437354/Amyloidosis_in_multiple_myeloma_or_without_apparent_cause_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/144/pg/2158 DB - PRIME DP - Unbound Medicine ER -