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Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in youngsters with non-ketotic insulin-dependent diabetes mellitus.
Horm Res. 1984; 20(4):213-7.HR

Abstract

Several parameters of thyroid function were studied in 112 non-ketoacidotic youngsters with insulin-dependent diabetes mellitus (IDDM). Levels of thyroxine (T4), reverse triiodothyronine (rT3), thyroxine-binding globulin (TBG) and T3 were lower than in controls, whereas FT4, and FT3 were normal. T4 levels in IDDM patients were positively related to T3, rT3 and TBG, and inversely related to haemoglobin A1 (HbA1). However, only 4 patients showed biochemical hypothyroidism (T4 less than 5 micrograms/100 ml), whereas their FT4, FT3 and thyroid-stimulating hormone (TSH) levels were normal. Concurrent variations of T3 and rT3 levels were found in IDDM patients; thus, their T3/rT3 ratios were stable or higher than in controls, indicating that peripheral deiodination of T4 is preferentially oriented to production of rT3 only during ketoacidosis. Although changes in thyroid function may reflect the degree of metabolic control of diabetes in a large population, the clinical usefulness of serum thyroid hormone measurements in an individual case still appears to be limited.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6439616

Citation

Bernasconi, S, et al. "Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in Youngsters With Non-ketotic Insulin-dependent Diabetes Mellitus." Hormone Research, vol. 20, no. 4, 1984, pp. 213-7.
Bernasconi S, Vanelli M, Nori G, et al. Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in youngsters with non-ketotic insulin-dependent diabetes mellitus. Horm Res. 1984;20(4):213-7.
Bernasconi, S., Vanelli, M., Nori, G., Siracusano, M. F., Marcellini, C., Butturini, A., & De Luca, F. (1984). Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in youngsters with non-ketotic insulin-dependent diabetes mellitus. Hormone Research, 20(4), 213-7.
Bernasconi S, et al. Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in Youngsters With Non-ketotic Insulin-dependent Diabetes Mellitus. Horm Res. 1984;20(4):213-7. PubMed PMID: 6439616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in youngsters with non-ketotic insulin-dependent diabetes mellitus. AU - Bernasconi,S, AU - Vanelli,M, AU - Nori,G, AU - Siracusano,M F, AU - Marcellini,C, AU - Butturini,A, AU - De Luca,F, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 213 EP - 7 JF - Hormone research JO - Horm. Res. VL - 20 IS - 4 N2 - Several parameters of thyroid function were studied in 112 non-ketoacidotic youngsters with insulin-dependent diabetes mellitus (IDDM). Levels of thyroxine (T4), reverse triiodothyronine (rT3), thyroxine-binding globulin (TBG) and T3 were lower than in controls, whereas FT4, and FT3 were normal. T4 levels in IDDM patients were positively related to T3, rT3 and TBG, and inversely related to haemoglobin A1 (HbA1). However, only 4 patients showed biochemical hypothyroidism (T4 less than 5 micrograms/100 ml), whereas their FT4, FT3 and thyroid-stimulating hormone (TSH) levels were normal. Concurrent variations of T3 and rT3 levels were found in IDDM patients; thus, their T3/rT3 ratios were stable or higher than in controls, indicating that peripheral deiodination of T4 is preferentially oriented to production of rT3 only during ketoacidosis. Although changes in thyroid function may reflect the degree of metabolic control of diabetes in a large population, the clinical usefulness of serum thyroid hormone measurements in an individual case still appears to be limited. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/6439616/Serum_TSH_T4_T3_FT4_FT3_rT3_and_TBG_in_youngsters_with_non_ketotic_insulin_dependent_diabetes_mellitus_ L2 - https://www.karger.com?DOI=10.1159/000179999 DB - PRIME DP - Unbound Medicine ER -