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A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types and dosages of progestogen.
Br J Obstet Gynaecol. 1984 Dec; 91(12):1254-60.BJ

Abstract

A prospective controlled study investigated the effects of oral contraceptives on blood pressure in 485 women who were between 17 and 46 years of age and had blood pressures of less than 140/90 mmHg at entry. The women were divided into seven groups depending on the chosen method of contraception: intrauterine device or barrier method (control group): ethinyl oestradiol 30 micrograms plus levonorgestrel 150 micrograms (Microgynon-30 or Ovranette); norethisterone 350 micrograms (Micronor); norgestrel 75 micrograms (Neogest); norethisterone oenanthate 200 mg intramuscularly every 2 months for the first 6 months, then every 3 months thereafter; ethinyl oestradiol 30 micrograms plus ethynodiol diacetate 2 mg (Conova-30); and ethynodiol diacetate 500 micrograms (Femulen). Blood pressures were measured every 3 months by the family planning clinic nurse under standardized conditions using an Elag-Köln automatic sphygmomanometer. After one year, blood pressure had risen significantly (P less than 0.05) in the 137 women taking ethinyl oestradiol plus levonorgestrel (mean systolic and diastolic rises 6.4 and 2.7 mmHg respectively) and in the 91 women taking ethinyl oestradiol plus ethynodiol diacetate (mean systolic and diastolic rises 6.2 and 3.0 mmHg respectively). The 94 women taking the progestogen-only preparations and the 143 women in the control group showed no increases in blood pressure. These data were confirmed after 2 years of follow-up.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6440589

Citation

Wilson, E S., et al. "A Prospective Controlled Study of the Effect On Blood Pressure of Contraceptive Preparations Containing Different Types and Dosages of Progestogen." British Journal of Obstetrics and Gynaecology, vol. 91, no. 12, 1984, pp. 1254-60.
Wilson ES, Cruickshank J, McMaster M, et al. A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types and dosages of progestogen. Br J Obstet Gynaecol. 1984;91(12):1254-60.
Wilson, E. S., Cruickshank, J., McMaster, M., & Weir, R. J. (1984). A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types and dosages of progestogen. British Journal of Obstetrics and Gynaecology, 91(12), 1254-60.
Wilson ES, et al. A Prospective Controlled Study of the Effect On Blood Pressure of Contraceptive Preparations Containing Different Types and Dosages of Progestogen. Br J Obstet Gynaecol. 1984;91(12):1254-60. PubMed PMID: 6440589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types and dosages of progestogen. AU - Wilson,E S, AU - Cruickshank,J, AU - McMaster,M, AU - Weir,R J, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez KW - Behavior KW - Biology KW - Blood Pressure--analysis KW - Blood Pressure--changes KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Progestin KW - Contraceptive Agents--side effects KW - Contraceptive Methods KW - Contraceptive Usage KW - Demographic Factors KW - Endocrine System KW - Estrogens--side effects KW - Ethinyl Estradiol KW - Family Planning KW - Fertility KW - Hemic System KW - Hormones KW - Iud KW - Levonorgestrel KW - Norethindrone KW - Norethindrone Enanthate KW - Norgestrel KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Population KW - Population Dynamics KW - Prospective Studies KW - Reproductive Behavior KW - Reproductive Control Agents KW - Research Methodology KW - Studies SP - 1254 EP - 60 JF - British journal of obstetrics and gynaecology JO - Br J Obstet Gynaecol VL - 91 IS - 12 N2 - A prospective controlled study investigated the effects of oral contraceptives on blood pressure in 485 women who were between 17 and 46 years of age and had blood pressures of less than 140/90 mmHg at entry. The women were divided into seven groups depending on the chosen method of contraception: intrauterine device or barrier method (control group): ethinyl oestradiol 30 micrograms plus levonorgestrel 150 micrograms (Microgynon-30 or Ovranette); norethisterone 350 micrograms (Micronor); norgestrel 75 micrograms (Neogest); norethisterone oenanthate 200 mg intramuscularly every 2 months for the first 6 months, then every 3 months thereafter; ethinyl oestradiol 30 micrograms plus ethynodiol diacetate 2 mg (Conova-30); and ethynodiol diacetate 500 micrograms (Femulen). Blood pressures were measured every 3 months by the family planning clinic nurse under standardized conditions using an Elag-Köln automatic sphygmomanometer. After one year, blood pressure had risen significantly (P less than 0.05) in the 137 women taking ethinyl oestradiol plus levonorgestrel (mean systolic and diastolic rises 6.4 and 2.7 mmHg respectively) and in the 91 women taking ethinyl oestradiol plus ethynodiol diacetate (mean systolic and diastolic rises 6.2 and 3.0 mmHg respectively). The 94 women taking the progestogen-only preparations and the 143 women in the control group showed no increases in blood pressure. These data were confirmed after 2 years of follow-up. SN - 0306-5456 UR - https://www.unboundmedicine.com/medline/citation/6440589/A_prospective_controlled_study_of_the_effect_on_blood_pressure_of_contraceptive_preparations_containing_different_types_and_dosages_of_progestogen_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6440589 DB - PRIME DP - Unbound Medicine ER -