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A randomized, single blind comparative trial of norethindrone enanthate and depo-medroxyprogesterone acetate in Bangladesh.
Contraception. 1980 Mar; 21(3):207-15.C

Abstract

A randomized, single blind comparative trial of norethindrone enanthate (NET-ENT) and depo-medroxyprogesterone acetate (DMPA) was conducted in the Model Clinic, Decca, Bangladesh, to determine if there were differences in reported side effects, reasons for discontinuation and discontinuation rates of these two injectables. On all follow-up visits the proportion of women reporting no bleeding (amenorrhea) was higher for the DMPA clients compared to the NET-ENT clients. Concurrent with these findings, the proportion of women reporting irregular bleeding was consistently higher for the NET-ENT clients. Concurrent with these findings, the proportion of women reporting irregular bleeding was consistently higher for the NET-ENT clients compared to those receiving DMPA. By the fourth injection, less than 15% of the clients in both drug groups still reported having regular cyclic bleeding (4 of the 26 DMPA clients and 4 of the 28 NET-ENT clients). Five of the 133 women on DMPA and 6 of the 106 women on NET-ENT became pregnant while using the injectables. At the end of one year of follow-up, 14 of the 133 DMPA and 14 of the 106 NET-ENT clients were still continuing (came back for a fifth injection).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6446442

Citation

Swenson, I, et al. "A Randomized, Single Blind Comparative Trial of Norethindrone Enanthate and Depo-medroxyprogesterone Acetate in Bangladesh." Contraception, vol. 21, no. 3, 1980, pp. 207-15.
Swenson I, Khan AR, Jahan FA. A randomized, single blind comparative trial of norethindrone enanthate and depo-medroxyprogesterone acetate in Bangladesh. Contraception. 1980;21(3):207-15.
Swenson, I., Khan, A. R., & Jahan, F. A. (1980). A randomized, single blind comparative trial of norethindrone enanthate and depo-medroxyprogesterone acetate in Bangladesh. Contraception, 21(3), 207-15.
Swenson I, Khan AR, Jahan FA. A Randomized, Single Blind Comparative Trial of Norethindrone Enanthate and Depo-medroxyprogesterone Acetate in Bangladesh. Contraception. 1980;21(3):207-15. PubMed PMID: 6446442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, single blind comparative trial of norethindrone enanthate and depo-medroxyprogesterone acetate in Bangladesh. AU - Swenson,I, AU - Khan,A R, AU - Jahan,F A, PY - 1980/3/1/pubmed PY - 1980/3/1/medline PY - 1980/3/1/entrez KW - Amenorrhea KW - Asia KW - Bangladesh KW - Bleeding KW - Comparative Studies KW - Contraception KW - Contraception Continuation KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents, Progestin--side effects KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Agents--side effects KW - Depo-provera--side effects KW - Developing Countries KW - Diseases KW - Family Planning KW - Injectables KW - Medroxyprogesterone Acetate--side effects KW - Menorrhagia KW - Menstruation Disorders KW - Metrorrhagia KW - Norethindrone--administraction and dosage KW - Norethindrone--side effects KW - Research Methodology KW - Signs And Symptoms KW - Southern Asia KW - Studies SP - 207 EP - 15 JF - Contraception JO - Contraception VL - 21 IS - 3 N2 - A randomized, single blind comparative trial of norethindrone enanthate (NET-ENT) and depo-medroxyprogesterone acetate (DMPA) was conducted in the Model Clinic, Decca, Bangladesh, to determine if there were differences in reported side effects, reasons for discontinuation and discontinuation rates of these two injectables. On all follow-up visits the proportion of women reporting no bleeding (amenorrhea) was higher for the DMPA clients compared to the NET-ENT clients. Concurrent with these findings, the proportion of women reporting irregular bleeding was consistently higher for the NET-ENT clients. Concurrent with these findings, the proportion of women reporting irregular bleeding was consistently higher for the NET-ENT clients compared to those receiving DMPA. By the fourth injection, less than 15% of the clients in both drug groups still reported having regular cyclic bleeding (4 of the 26 DMPA clients and 4 of the 28 NET-ENT clients). Five of the 133 women on DMPA and 6 of the 106 women on NET-ENT became pregnant while using the injectables. At the end of one year of follow-up, 14 of the 133 DMPA and 14 of the 106 NET-ENT clients were still continuing (came back for a fifth injection). SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/6446442/A_randomized_single_blind_comparative_trial_of_norethindrone_enanthate_and_depo_medroxyprogesterone_acetate_in_Bangladesh_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(80)90001-3 DB - PRIME DP - Unbound Medicine ER -