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Effect of cadmium on ATPase activities in rats fed on iron-deficient and sufficient diets.
J Environ Sci Health B 1980; 15(4):379-93JE

Abstract

Male Sprague-Dawley rats were fed on different levels of cadmium mixed with purified diets containing iron or no iron for 8 weeks. The body weight gain, tissue weights, hemoglobin, hematocrit, liver and brain ATPase were measured at 2, 4 and 8 weeks after feeding. The hemoglobin and hematocrit values were the same in all rats fed on cadmium. The rats fed on iron-deficient diets mixed with cadmium showed a significant decrease in body weight gain. However, the rats receiving only the 100 ppm of cadmium in iron-sufficient diet showed a significant decrease in body weight gain. There were no significant changes in the weights of thymus, spleen, kidney, heart, brain and testes. However, the liver weights were decreased in the highest treatment of cadmium but the liver weight/body ratios were uneffected. Na+-K+ activated ATPase activity in brains of rats fed on cadmium were significantly decreased at 2, 4 and 8 weeks of treatment. The decrease was more pronounced in rats fed on iron-deficient diets. Oligomycin-sensitive (Mitochondrial) Mg2+ ATPase activity was also significantly decreased in liver and brain tissues of rats fed on cadmium. Oligomycin-insensitive Mg2+ ATPase activity, however, was not altered in any tissues tested. It appears that cadmium may be interfering with energy (ATP) production and utilization processes in rat brain and liver tissues.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6447170

Citation

Chetty, K N., et al. "Effect of Cadmium On ATPase Activities in Rats Fed On Iron-deficient and Sufficient Diets." Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, vol. 15, no. 4, 1980, pp. 379-93.
Chetty KN, Drummond L, Desaiah D. Effect of cadmium on ATPase activities in rats fed on iron-deficient and sufficient diets. J Environ Sci Health B. 1980;15(4):379-93.
Chetty, K. N., Drummond, L., & Desaiah, D. (1980). Effect of cadmium on ATPase activities in rats fed on iron-deficient and sufficient diets. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, 15(4), pp. 379-93.
Chetty KN, Drummond L, Desaiah D. Effect of Cadmium On ATPase Activities in Rats Fed On Iron-deficient and Sufficient Diets. J Environ Sci Health B. 1980;15(4):379-93. PubMed PMID: 6447170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cadmium on ATPase activities in rats fed on iron-deficient and sufficient diets. AU - Chetty,K N, AU - Drummond,L, AU - Desaiah,D, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 379 EP - 93 JF - Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes JO - J Environ Sci Health B VL - 15 IS - 4 N2 - Male Sprague-Dawley rats were fed on different levels of cadmium mixed with purified diets containing iron or no iron for 8 weeks. The body weight gain, tissue weights, hemoglobin, hematocrit, liver and brain ATPase were measured at 2, 4 and 8 weeks after feeding. The hemoglobin and hematocrit values were the same in all rats fed on cadmium. The rats fed on iron-deficient diets mixed with cadmium showed a significant decrease in body weight gain. However, the rats receiving only the 100 ppm of cadmium in iron-sufficient diet showed a significant decrease in body weight gain. There were no significant changes in the weights of thymus, spleen, kidney, heart, brain and testes. However, the liver weights were decreased in the highest treatment of cadmium but the liver weight/body ratios were uneffected. Na+-K+ activated ATPase activity in brains of rats fed on cadmium were significantly decreased at 2, 4 and 8 weeks of treatment. The decrease was more pronounced in rats fed on iron-deficient diets. Oligomycin-sensitive (Mitochondrial) Mg2+ ATPase activity was also significantly decreased in liver and brain tissues of rats fed on cadmium. Oligomycin-insensitive Mg2+ ATPase activity, however, was not altered in any tissues tested. It appears that cadmium may be interfering with energy (ATP) production and utilization processes in rat brain and liver tissues. SN - 0360-1234 UR - https://www.unboundmedicine.com/medline/citation/6447170/Effect_of_cadmium_on_ATPase_activities_in_rats_fed_on_iron_deficient_and_sufficient_diets_ L2 - http://www.tandfonline.com/doi/full/10.1080/10934528009374939 DB - PRIME DP - Unbound Medicine ER -