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Analytical methods for the determination of bromperidol in plasma.
Acta Psychiatr Belg. 1978 Jan-Feb; 78(1):64-8.AP

Abstract

The treatment with neuroleptic drugs, such as the butyrophenones, has been based on clinical empiricism, rather than on pharmacokinetic knowledge or on a clear understanding of the mode of action of the drugs. To obtain pharmacokinetic data a specific and sensitive analytical method is necessary. The determination of butyrophenones in a biological medium poses many analytical problems, due to the low dose of these drugs. Very recently Forsman published a pharmacokinetic study of haloperidol in man by electron capture detection. No such study is available for bromperidol. In our paper, we will present comparative data for the quantitative determination of bromperidol by mass fragmentography, gas chromatography with electron capture detection, and radioimmunoassay. Our results show that for the determination of bromperidol in plasma, only radioimmunoassay is sensitive enough to allow the easy determination of the low plasma levels to be expected for bromperidol.

Authors

Van den Eeckhout E
No affiliation info available
Belpaire F
No affiliation info available

MeSH

BromineChromatography, GasGas Chromatography-Mass SpectrometryHaloperidolHumansMethodsRadioimmunoassay

Pub Type(s)

Journal Article

Language

eng

PubMed ID

645408

Citation

Van den Eeckhout, E, and F Belpaire. "Analytical Methods for the Determination of Bromperidol in Plasma." Acta Psychiatrica Belgica, vol. 78, no. 1, 1978, pp. 64-8.
Van den Eeckhout E, Belpaire F. Analytical methods for the determination of bromperidol in plasma. Acta Psychiatr Belg. 1978;78(1):64-8.
Van den Eeckhout, E., & Belpaire, F. (1978). Analytical methods for the determination of bromperidol in plasma. Acta Psychiatrica Belgica, 78(1), 64-8.
Van den Eeckhout E, Belpaire F. Analytical Methods for the Determination of Bromperidol in Plasma. Acta Psychiatr Belg. 1978 Jan-Feb;78(1):64-8. PubMed PMID: 645408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical methods for the determination of bromperidol in plasma. AU - Van den Eeckhout,E, AU - Belpaire,F, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 64 EP - 8 JF - Acta psychiatrica Belgica JO - Acta Psychiatr Belg VL - 78 IS - 1 N2 - The treatment with neuroleptic drugs, such as the butyrophenones, has been based on clinical empiricism, rather than on pharmacokinetic knowledge or on a clear understanding of the mode of action of the drugs. To obtain pharmacokinetic data a specific and sensitive analytical method is necessary. The determination of butyrophenones in a biological medium poses many analytical problems, due to the low dose of these drugs. Very recently Forsman published a pharmacokinetic study of haloperidol in man by electron capture detection. No such study is available for bromperidol. In our paper, we will present comparative data for the quantitative determination of bromperidol by mass fragmentography, gas chromatography with electron capture detection, and radioimmunoassay. Our results show that for the determination of bromperidol in plasma, only radioimmunoassay is sensitive enough to allow the easy determination of the low plasma levels to be expected for bromperidol. SN - 0300-8967 UR - https://www.unboundmedicine.com/medline/citation/645408/Analytical_methods_for_the_determination_of_bromperidol_in_plasma_ DB - PRIME DP - Unbound Medicine ER -