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The effects of thyroid status on some properties of rat fast-twitch muscle.
J Muscle Res Cell Motil 1981; 2(3):307-20JM

Abstract

The effects of different thyroid states on some histochemical and biochemical properties of fast-twitch muscle were studied using rat extensor digitorum longus (EDL) muscle. This muscle was found to be much less responsive to thyroidal influence than the slow-twitch soleus muscle. In EDL muscles of hypothyroid rats, fast leads to slow conversions were observed in fibre type composition, myosin ATPase activity and light chain pattern, and in the subunit composition of lactate dehydrogenase, while the only significant slow leads to fast conversion observed in thyrotoxicosis was a decrease in the proportion of slow-oxidative fibres. Denervation of the hypothyroid muscle produced the highest degree of fast leads to slow transformation. These findings support the view that denervation and dysthyreosis alter gene expression in muscle by independent mechanisms.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6457058

Citation

Nwoye, L, and W F. Mommaerts. "The Effects of Thyroid Status On some Properties of Rat Fast-twitch Muscle." Journal of Muscle Research and Cell Motility, vol. 2, no. 3, 1981, pp. 307-20.
Nwoye L, Mommaerts WF. The effects of thyroid status on some properties of rat fast-twitch muscle. J Muscle Res Cell Motil. 1981;2(3):307-20.
Nwoye, L., & Mommaerts, W. F. (1981). The effects of thyroid status on some properties of rat fast-twitch muscle. Journal of Muscle Research and Cell Motility, 2(3), pp. 307-20.
Nwoye L, Mommaerts WF. The Effects of Thyroid Status On some Properties of Rat Fast-twitch Muscle. J Muscle Res Cell Motil. 1981;2(3):307-20. PubMed PMID: 6457058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of thyroid status on some properties of rat fast-twitch muscle. AU - Nwoye,L, AU - Mommaerts,W F, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - 307 EP - 20 JF - Journal of muscle research and cell motility JO - J. Muscle Res. Cell. Motil. VL - 2 IS - 3 N2 - The effects of different thyroid states on some histochemical and biochemical properties of fast-twitch muscle were studied using rat extensor digitorum longus (EDL) muscle. This muscle was found to be much less responsive to thyroidal influence than the slow-twitch soleus muscle. In EDL muscles of hypothyroid rats, fast leads to slow conversions were observed in fibre type composition, myosin ATPase activity and light chain pattern, and in the subunit composition of lactate dehydrogenase, while the only significant slow leads to fast conversion observed in thyrotoxicosis was a decrease in the proportion of slow-oxidative fibres. Denervation of the hypothyroid muscle produced the highest degree of fast leads to slow transformation. These findings support the view that denervation and dysthyreosis alter gene expression in muscle by independent mechanisms. SN - 0142-4319 UR - https://www.unboundmedicine.com/medline/citation/6457058/The_effects_of_thyroid_status_on_some_properties_of_rat_fast-twitch_muscle L2 - https://medlineplus.gov/hyperthyroidism.html DB - PRIME DP - Unbound Medicine ER -