Tags

Type your tag names separated by a space and hit enter

[Diphosphonates in the treatment of bone metastases].
Schweiz Med Wochenschr. 1981 Dec 05; 111(49):1878-82.SM

Abstract

The diphosphonates are a group of phosphate compounds which inhibit the growth and dissolution of apatite crystals. These drugs have similar biological effects on bone by inhibiting the osteoclasts, and are also active in preventing pathological calcifications. The diphosphonates have been used successfully in various bone diseases and are now currently used for bone scanning. They are also considered one of the best treatments for Paget's disease. Several experiments in vitro and in vivo have suggested that the diphosphonates are active against bone metastases. Clinical trials have been undertaken and have shown that these compounds are active against malignant hypercalcemia. Further, they may delay the extension of bone destruction due to malignancy.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

6460313

Citation

Jung, A, and H Fleisch. "[Diphosphonates in the Treatment of Bone Metastases]." Schweizerische Medizinische Wochenschrift, vol. 111, no. 49, 1981, pp. 1878-82.
Jung A, Fleisch H. [Diphosphonates in the treatment of bone metastases]. Schweiz Med Wochenschr. 1981;111(49):1878-82.
Jung, A., & Fleisch, H. (1981). [Diphosphonates in the treatment of bone metastases]. Schweizerische Medizinische Wochenschrift, 111(49), 1878-82.
Jung A, Fleisch H. [Diphosphonates in the Treatment of Bone Metastases]. Schweiz Med Wochenschr. 1981 Dec 5;111(49):1878-82. PubMed PMID: 6460313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diphosphonates in the treatment of bone metastases]. AU - Jung,A, AU - Fleisch,H, PY - 1981/12/5/pubmed PY - 1981/12/5/medline PY - 1981/12/5/entrez SP - 1878 EP - 82 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 111 IS - 49 N2 - The diphosphonates are a group of phosphate compounds which inhibit the growth and dissolution of apatite crystals. These drugs have similar biological effects on bone by inhibiting the osteoclasts, and are also active in preventing pathological calcifications. The diphosphonates have been used successfully in various bone diseases and are now currently used for bone scanning. They are also considered one of the best treatments for Paget's disease. Several experiments in vitro and in vivo have suggested that the diphosphonates are active against bone metastases. Clinical trials have been undertaken and have shown that these compounds are active against malignant hypercalcemia. Further, they may delay the extension of bone destruction due to malignancy. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/6460313/[Diphosphonates_in_the_treatment_of_bone_metastases]_ L2 - https://medlineplus.gov/bonecancer.html DB - PRIME DP - Unbound Medicine ER -