Tags

Type your tag names separated by a space and hit enter

Gastric carcinoma and pernicious anaemia in long-term endoscopic follow-up of subjects with gastric polyps.
Scand J Gastroenterol. 1984 Jun; 19(4):535-40.SJ

Abstract

The starting material consisted of 357 subjects with gastric polyps found at endoscopy. Histologically, these cases were divided in four groups: adenoma, 8%; hyperplastic polyp, 34%; foveolar hyperplasia, 21%; and inflammatory polyp, 36%. Of these 210 patients were for various reasons no longer available for follow-up study. Endoscopic follow-up study for about 8 years (range, 5-15.5 years) was performed in 147 patients. At the follow-up examination, in 103 patients morphologic signs and in 92 of these immunological and functional signs of pernicious anaemia were examined. The prevalences of severe atrophic gastritis affecting mainly the body mucosa (26%), parietal cell and/or intrinsic factor blocking antibodies (25%), low serum vitamin B12 levels (8%), and overt pernicious anaemia (treated and new cases, 11%) were significantly higher than in equal numbers of age- and sex-matched controls examined in a similar manner. Gastric cancer was found in 3 (2%) cases followed up for more than 5 years. This is seven times the expected incidence, with a 95% confidence interval of the risk ratio (1.5-20.9). The high frequency of gastric cancer and pernicious anemia emphasizes the importance of long-term endoscopic follow-up study of patients with gastric polyps.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6463578

Citation

Laxén, F. "Gastric Carcinoma and Pernicious Anaemia in Long-term Endoscopic Follow-up of Subjects With Gastric Polyps." Scandinavian Journal of Gastroenterology, vol. 19, no. 4, 1984, pp. 535-40.
Laxén F. Gastric carcinoma and pernicious anaemia in long-term endoscopic follow-up of subjects with gastric polyps. Scand J Gastroenterol. 1984;19(4):535-40.
Laxén, F. (1984). Gastric carcinoma and pernicious anaemia in long-term endoscopic follow-up of subjects with gastric polyps. Scandinavian Journal of Gastroenterology, 19(4), 535-40.
Laxén F. Gastric Carcinoma and Pernicious Anaemia in Long-term Endoscopic Follow-up of Subjects With Gastric Polyps. Scand J Gastroenterol. 1984;19(4):535-40. PubMed PMID: 6463578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric carcinoma and pernicious anaemia in long-term endoscopic follow-up of subjects with gastric polyps. A1 - Laxén,F, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 535 EP - 40 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 19 IS - 4 N2 - The starting material consisted of 357 subjects with gastric polyps found at endoscopy. Histologically, these cases were divided in four groups: adenoma, 8%; hyperplastic polyp, 34%; foveolar hyperplasia, 21%; and inflammatory polyp, 36%. Of these 210 patients were for various reasons no longer available for follow-up study. Endoscopic follow-up study for about 8 years (range, 5-15.5 years) was performed in 147 patients. At the follow-up examination, in 103 patients morphologic signs and in 92 of these immunological and functional signs of pernicious anaemia were examined. The prevalences of severe atrophic gastritis affecting mainly the body mucosa (26%), parietal cell and/or intrinsic factor blocking antibodies (25%), low serum vitamin B12 levels (8%), and overt pernicious anaemia (treated and new cases, 11%) were significantly higher than in equal numbers of age- and sex-matched controls examined in a similar manner. Gastric cancer was found in 3 (2%) cases followed up for more than 5 years. This is seven times the expected incidence, with a 95% confidence interval of the risk ratio (1.5-20.9). The high frequency of gastric cancer and pernicious anemia emphasizes the importance of long-term endoscopic follow-up study of patients with gastric polyps. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/6463578/Gastric_carcinoma_and_pernicious_anaemia_in_long_term_endoscopic_follow_up_of_subjects_with_gastric_polyps_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -