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Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium).
Tropenmed Parasitol. 1984 Jun; 35(2):95-9.TP

Abstract

158 school children from Lambarene and its surroundings suffering from intestinal manifestations of schistosomiasis due to Schistosoma intercalatum, Schistosoma haematobium, or mixed infections were randomly allocated to patient groups to be treated with oltipraz and praziquantel respectively. Oltipraz was tested in three dosage regimens, i.e., 1 X 25 mg/kg, 1 X 35 mg/kg, and 2 X 20 mg/kg and compared to 2 X 30 mg/kg praziquantel in each of the treatment groups. 45 days and 90 days after treatment, the children were thoroughly investigated. Rectoscopy was only performed in part of the children. The number of children with viable egg excretion had significantly dropped after therapy (p less than 0.001). Parasitological cure after 90 days was obtained in 86% of patients treated with 2 X 20 mg oltipraz and 90% of patients treated by praziquantel. A comparative effectiveness was achieved with the other dosage regimens of oltipraz, too. The efficacy of the new schistosomicid oltipraz is identical with that of praziquantel for patients with intestinal manifestation. The rectal biopsies taken 45 days and 90 days after therapy still contained numerous eggs which were mostly calcified or granulated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6464192

Citation

Kern, P, et al. "Comparative Study of Oltipraz Versus Praziquantel for Treatment of Schistosomiasis With Intestinal Manifestation in the Gabon (Schistosoma Intercalatum and S. Haematobium)." Tropenmedizin Und Parasitologie, vol. 35, no. 2, 1984, pp. 95-9.
Kern P, Burchard GD, Dietrich M. Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium). Tropenmed Parasitol. 1984;35(2):95-9.
Kern, P., Burchard, G. D., & Dietrich, M. (1984). Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium). Tropenmedizin Und Parasitologie, 35(2), 95-9.
Kern P, Burchard GD, Dietrich M. Comparative Study of Oltipraz Versus Praziquantel for Treatment of Schistosomiasis With Intestinal Manifestation in the Gabon (Schistosoma Intercalatum and S. Haematobium). Tropenmed Parasitol. 1984;35(2):95-9. PubMed PMID: 6464192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium). AU - Kern,P, AU - Burchard,G D, AU - Dietrich,M, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 95 EP - 9 JF - Tropenmedizin und Parasitologie JO - Tropenmed Parasitol VL - 35 IS - 2 N2 - 158 school children from Lambarene and its surroundings suffering from intestinal manifestations of schistosomiasis due to Schistosoma intercalatum, Schistosoma haematobium, or mixed infections were randomly allocated to patient groups to be treated with oltipraz and praziquantel respectively. Oltipraz was tested in three dosage regimens, i.e., 1 X 25 mg/kg, 1 X 35 mg/kg, and 2 X 20 mg/kg and compared to 2 X 30 mg/kg praziquantel in each of the treatment groups. 45 days and 90 days after treatment, the children were thoroughly investigated. Rectoscopy was only performed in part of the children. The number of children with viable egg excretion had significantly dropped after therapy (p less than 0.001). Parasitological cure after 90 days was obtained in 86% of patients treated with 2 X 20 mg oltipraz and 90% of patients treated by praziquantel. A comparative effectiveness was achieved with the other dosage regimens of oltipraz, too. The efficacy of the new schistosomicid oltipraz is identical with that of praziquantel for patients with intestinal manifestation. The rectal biopsies taken 45 days and 90 days after therapy still contained numerous eggs which were mostly calcified or granulated. SN - 0303-4208 UR - https://www.unboundmedicine.com/medline/citation/6464192/Comparative_study_of_oltipraz_versus_praziquantel_for_treatment_of_schistosomiasis_with_intestinal_manifestation_in_the_Gabon__Schistosoma_intercalatum_and_S__haematobium__ DB - PRIME DP - Unbound Medicine ER -