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Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig.
Acta Otolaryngol. 1984 Jul-Aug; 98(1-2):98-104.AO

Abstract

Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributions. Both Na and K concentrations were reduced in serum. In CSF, the Na concentration was markedly depressed, while the K concentration remained unchanged. Scala tympani perilymph showed a pattern of electrolyte changes similar to that in CSF. In scala vestibuli perilymph, the Na concentration was unaltered, but the K concentration was lowered. Cochlear endolymph exhibited no change of the Na concentration but there was a marked decrease in the K concentration. These changes are thought to be attributable to the indirect blockage of energy producing systems in membrane transport in the inner ear by the reserpine-induced depletion of catecholamines.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6464730

Citation

Kanoh, N, and K Makimoto. "Effects of Reserpinization On the Electrolytes Distribution in Inner Ear Fluids of Guinea Pig." Acta Oto-laryngologica, vol. 98, no. 1-2, 1984, pp. 98-104.
Kanoh N, Makimoto K. Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig. Acta Otolaryngol. 1984;98(1-2):98-104.
Kanoh, N., & Makimoto, K. (1984). Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig. Acta Oto-laryngologica, 98(1-2), 98-104.
Kanoh N, Makimoto K. Effects of Reserpinization On the Electrolytes Distribution in Inner Ear Fluids of Guinea Pig. Acta Otolaryngol. 1984 Jul-Aug;98(1-2):98-104. PubMed PMID: 6464730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig. AU - Kanoh,N, AU - Makimoto,K, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 98 EP - 104 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 98 IS - 1-2 N2 - Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributions. Both Na and K concentrations were reduced in serum. In CSF, the Na concentration was markedly depressed, while the K concentration remained unchanged. Scala tympani perilymph showed a pattern of electrolyte changes similar to that in CSF. In scala vestibuli perilymph, the Na concentration was unaltered, but the K concentration was lowered. Cochlear endolymph exhibited no change of the Na concentration but there was a marked decrease in the K concentration. These changes are thought to be attributable to the indirect blockage of energy producing systems in membrane transport in the inner ear by the reserpine-induced depletion of catecholamines. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/6464730/Effects_of_reserpinization_on_the_electrolytes_distribution_in_inner_ear_fluids_of_guinea_pig_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016488409107540 DB - PRIME DP - Unbound Medicine ER -