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Schilling evaluation of pernicious anemia: current status.
J Nucl Med. 1984 Sep; 25(9):1032-9.JN

Abstract

The Schilling examination remains a popular means of evaluating in vivo absorption of vitamin B12. When absorption is abnormally low, the test may be repeated with addition of exogenous intrinsic factor (IF) in order to correct the IF deficiency that characterizes pernicious anemia. A dual-isotope variation provides a means of performing both stages of the test simultaneously, thereby speeding up the test and reducing dependence on complete urine collection. The dual-tracer test depends on no exchange of B12 moieties on the IF molecule. In vitro studies suggest that this exchange does take place, in a manner dependent on time, temperature, and pH. Furthermore, in vivo studies indicate that, when administered simultaneously, the absorption of unbound B12 is elevated, and IF-bound B12 is reduced, in pernicious-anemia patients, relative to the classic two-stage examination. A number of clinical studies indicate significant difficulty in resolving clinical diagnoses with the dual-tracer test. The potential weaknesses of the test discussed herein can be overcome by temporally separating the administration of the two B12 doses and by treating secondary malabsorption where it exists. An algorithm is offered for selecting the most suitable variation of the Schilling test to improve the accuracy of test results and the ease of performance.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6470805

Citation

Zuckier, L S., and L R. Chervu. "Schilling Evaluation of Pernicious Anemia: Current Status." Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, vol. 25, no. 9, 1984, pp. 1032-9.
Zuckier LS, Chervu LR. Schilling evaluation of pernicious anemia: current status. J Nucl Med. 1984;25(9):1032-9.
Zuckier, L. S., & Chervu, L. R. (1984). Schilling evaluation of pernicious anemia: current status. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 25(9), 1032-9.
Zuckier LS, Chervu LR. Schilling Evaluation of Pernicious Anemia: Current Status. J Nucl Med. 1984;25(9):1032-9. PubMed PMID: 6470805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Schilling evaluation of pernicious anemia: current status. AU - Zuckier,L S, AU - Chervu,L R, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 1032 EP - 9 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JO - J Nucl Med VL - 25 IS - 9 N2 - The Schilling examination remains a popular means of evaluating in vivo absorption of vitamin B12. When absorption is abnormally low, the test may be repeated with addition of exogenous intrinsic factor (IF) in order to correct the IF deficiency that characterizes pernicious anemia. A dual-isotope variation provides a means of performing both stages of the test simultaneously, thereby speeding up the test and reducing dependence on complete urine collection. The dual-tracer test depends on no exchange of B12 moieties on the IF molecule. In vitro studies suggest that this exchange does take place, in a manner dependent on time, temperature, and pH. Furthermore, in vivo studies indicate that, when administered simultaneously, the absorption of unbound B12 is elevated, and IF-bound B12 is reduced, in pernicious-anemia patients, relative to the classic two-stage examination. A number of clinical studies indicate significant difficulty in resolving clinical diagnoses with the dual-tracer test. The potential weaknesses of the test discussed herein can be overcome by temporally separating the administration of the two B12 doses and by treating secondary malabsorption where it exists. An algorithm is offered for selecting the most suitable variation of the Schilling test to improve the accuracy of test results and the ease of performance. SN - 0161-5505 UR - https://www.unboundmedicine.com/medline/citation/6470805/Schilling_evaluation_of_pernicious_anemia:_current_status_ L2 - http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=6470805 DB - PRIME DP - Unbound Medicine ER -