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Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking.
N Engl J Med 1984; 311(13):828-32NEJM

Abstract

Despite recognition of the deleterious effects of passive smoking, quantitative information on the intake of environmental tobacco smoke is still lacking. Cotinine is the major metabolite of nicotine found in the urine. We have examined the relationship between urinary cotinine excretion in 472 nonsmokers and the smokiness of their environment. The urinary cotinine levels of nonsmokers who lived with smokers were higher than those of nonsmokers who did not, increasing with the combined daily cigarette consumption of smokers in the family. The urinary cotinine values of nonsmokers who worked with smokers were also higher than those of nonsmokers who did not, increasing with the number of smokers in the workroom. The presence of smokers in both the home and the workplace also increased the cotinine levels. Urban nonsmokers had more cotinine in their urine than rural nonsmokers. We conclude that the deleterious effects of passive smoking may occur in proportion to the exposure of nonsmokers to smokers in the home, the workplace, and the community.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6472384

Citation

Matsukura, S, et al. "Effects of Environmental Tobacco Smoke On Urinary Cotinine Excretion in Nonsmokers. Evidence for Passive Smoking." The New England Journal of Medicine, vol. 311, no. 13, 1984, pp. 828-32.
Matsukura S, Taminato T, Kitano N, et al. Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking. N Engl J Med. 1984;311(13):828-32.
Matsukura, S., Taminato, T., Kitano, N., Seino, Y., Hamada, H., Uchihashi, M., ... Hirata, Y. (1984). Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking. The New England Journal of Medicine, 311(13), pp. 828-32.
Matsukura S, et al. Effects of Environmental Tobacco Smoke On Urinary Cotinine Excretion in Nonsmokers. Evidence for Passive Smoking. N Engl J Med. 1984 Sep 27;311(13):828-32. PubMed PMID: 6472384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking. AU - Matsukura,S, AU - Taminato,T, AU - Kitano,N, AU - Seino,Y, AU - Hamada,H, AU - Uchihashi,M, AU - Nakajima,H, AU - Hirata,Y, PY - 1984/9/27/pubmed PY - 1984/9/27/medline PY - 1984/9/27/entrez SP - 828 EP - 32 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 311 IS - 13 N2 - Despite recognition of the deleterious effects of passive smoking, quantitative information on the intake of environmental tobacco smoke is still lacking. Cotinine is the major metabolite of nicotine found in the urine. We have examined the relationship between urinary cotinine excretion in 472 nonsmokers and the smokiness of their environment. The urinary cotinine levels of nonsmokers who lived with smokers were higher than those of nonsmokers who did not, increasing with the combined daily cigarette consumption of smokers in the family. The urinary cotinine values of nonsmokers who worked with smokers were also higher than those of nonsmokers who did not, increasing with the number of smokers in the workroom. The presence of smokers in both the home and the workplace also increased the cotinine levels. Urban nonsmokers had more cotinine in their urine than rural nonsmokers. We conclude that the deleterious effects of passive smoking may occur in proportion to the exposure of nonsmokers to smokers in the home, the workplace, and the community. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6472384/Effects_of_environmental_tobacco_smoke_on_urinary_cotinine_excretion_in_nonsmokers__Evidence_for_passive_smoking_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198409273111305?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -