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Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.
Br Med J. 1978 Jun 03; 1(6125):1453-5.BM

Abstract

The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream after the transcobalamin II-B12 complex is cleared by the liver and it is then excreted into the urine during the Schilling test.

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Authors

Chanarin I
No affiliation info available
Muir M
No affiliation info available
Hughes A
No affiliation info available
Hoffbrand AV
No affiliation info available

MeSH

AgedBlood ProteinsHumansIntestinal AbsorptionIntestinal MucosaMiddle AgedSchilling TestTranscobalaminsVitamin B 12

Pub Type(s)

Journal Article

Language

eng

PubMed ID

647333

Citation

Chanarin, I, et al. "Evidence for Intestinal Origin of Transcobalamin II During Vitamin B12 Absorption." British Medical Journal, vol. 1, no. 6125, 1978, pp. 1453-5.
Chanarin I, Muir M, Hughes A, et al. Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption. Br Med J. 1978;1(6125):1453-5.
Chanarin, I., Muir, M., Hughes, A., & Hoffbrand, A. V. (1978). Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption. British Medical Journal, 1(6125), 1453-5.
Chanarin I, et al. Evidence for Intestinal Origin of Transcobalamin II During Vitamin B12 Absorption. Br Med J. 1978 Jun 3;1(6125):1453-5. PubMed PMID: 647333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption. AU - Chanarin,I, AU - Muir,M, AU - Hughes,A, AU - Hoffbrand,A V, PY - 1978/6/3/pubmed PY - 1978/6/3/medline PY - 1978/6/3/entrez SP - 1453 EP - 5 JF - British medical journal JO - Br Med J VL - 1 IS - 6125 N2 - The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream after the transcobalamin II-B12 complex is cleared by the liver and it is then excreted into the urine during the Schilling test. SN - 0007-1447 UR - https://www.unboundmedicine.com/medline/citation/647333/Evidence_for_intestinal_origin_of_transcobalamin_II_during_vitamin_B12_absorption_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/647333/ DB - PRIME DP - Unbound Medicine ER -