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Incidence of thyroid cancer in women in relation to reproductive and hormonal factors.
Am J Epidemiol. 1984 Sep; 120(3):423-35.AJ

Abstract

Female residents of western Washington state aged 18-80 years in whom thyroid cancer was diagnosed between January 1974 and December 1979 were interviewed concerning their reproductive histories and their prior use of exogenous estrogens. Their responses were compared with those of a sample of women from the same population, individually matched to cases on telephone prefix. Use of each of several estrogen-containing preparations was associated with a small increased risk of thyroid cancer; parous women who had ever used a lactation suppressant had 1.7 times the risk of parous nonusers (95% confidence interval, 1.1-2.8); ever users of oral contraceptives had 1.6 times the risk of never users (95% confidence interval, 0.98-2.5); and ever users of postmenopausal estrogens had 1.4 times the risk of never users (95% confidence interval, 0.89-2.3). Among the low risk group of women, i.e., those who had never undergone radiation therapy and who had never had a goiter, a history of one or more pregnancies was also associated with a small increase in the risk of thyroid cancer (relative risk = 1.8, 95% confidence interval, 1.1-3.1). However, no increase in risk with increasing duration of use of oral contraceptives or menopausal estrogens or with increasing number of pregnancies was noted. While pregnancy and use of exogenous estrogens have an impact on the production of thyroid-stimulating hormone, their effect on the incidence of thyroid carcinoma, if present at all, appears to be small.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6475918

Citation

McTiernan, A M., et al. "Incidence of Thyroid Cancer in Women in Relation to Reproductive and Hormonal Factors." American Journal of Epidemiology, vol. 120, no. 3, 1984, pp. 423-35.
McTiernan AM, Weiss NS, Daling JR. Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. Am J Epidemiol. 1984;120(3):423-35.
McTiernan, A. M., Weiss, N. S., & Daling, J. R. (1984). Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. American Journal of Epidemiology, 120(3), 423-35.
McTiernan AM, Weiss NS, Daling JR. Incidence of Thyroid Cancer in Women in Relation to Reproductive and Hormonal Factors. Am J Epidemiol. 1984;120(3):423-35. PubMed PMID: 6475918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. AU - McTiernan,A M, AU - Weiss,N S, AU - Daling,J R, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez KW - Age Factors KW - Americas KW - Anatomy KW - Anthropometry KW - Biology KW - Body Weight KW - Cancer KW - Contraception KW - Contraceptive Agents, Female KW - Control Groups KW - Data Collection KW - Developed Countries KW - Developing Countries KW - Diseases KW - Economic Factors KW - Endocrine Effects KW - Endocrine System KW - Estrogens KW - Family And Household KW - Family Characteristics KW - Histology KW - Hormones KW - Incidence KW - Macroeconomic Factors KW - Measurement KW - Menarche KW - Menstruation KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives KW - Physiology KW - Population At Risk KW - Population Characteristics KW - Pregnancy KW - Pregnancy Rate KW - Religion KW - Reproduction KW - Reproductive Control Agents KW - Research Methodology KW - Socioeconomic Factors KW - United States KW - Washington SP - 423 EP - 35 JF - American journal of epidemiology JO - Am J Epidemiol VL - 120 IS - 3 N2 - Female residents of western Washington state aged 18-80 years in whom thyroid cancer was diagnosed between January 1974 and December 1979 were interviewed concerning their reproductive histories and their prior use of exogenous estrogens. Their responses were compared with those of a sample of women from the same population, individually matched to cases on telephone prefix. Use of each of several estrogen-containing preparations was associated with a small increased risk of thyroid cancer; parous women who had ever used a lactation suppressant had 1.7 times the risk of parous nonusers (95% confidence interval, 1.1-2.8); ever users of oral contraceptives had 1.6 times the risk of never users (95% confidence interval, 0.98-2.5); and ever users of postmenopausal estrogens had 1.4 times the risk of never users (95% confidence interval, 0.89-2.3). Among the low risk group of women, i.e., those who had never undergone radiation therapy and who had never had a goiter, a history of one or more pregnancies was also associated with a small increase in the risk of thyroid cancer (relative risk = 1.8, 95% confidence interval, 1.1-3.1). However, no increase in risk with increasing duration of use of oral contraceptives or menopausal estrogens or with increasing number of pregnancies was noted. While pregnancy and use of exogenous estrogens have an impact on the production of thyroid-stimulating hormone, their effect on the incidence of thyroid carcinoma, if present at all, appears to be small. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/6475918/Incidence_of_thyroid_cancer_in_women_in_relation_to_reproductive_and_hormonal_factors_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a113907 DB - PRIME DP - Unbound Medicine ER -