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The development of wearable-type artificial endocrine pancreas and its usefulness in glycaemic control of human diabetes mellitus.
Biomed Biochim Acta. 1984; 43(5):561-8.BB

Abstract

We have succeeded in miniaturizing a glucose monitoring system into a needle-type which preserves the characteristics suitable for application in a wearable closed-loop control system. The wearable artificial endocrine pancreas (12 X 15 X 6 cm, 400 g) consists of the sensor, a microcomputer which calculates the insulin and glucagon infusion rates and of a 2-syringe driving system. The device succeeded in controlling glycaemia perfectly in depancreatized dogs for a period of 3 days, and with replacement of subcutaneously inserted sensor for up to 7 days. When glucose monitoring by a needle-type glucose sensor inserted into subcutaneous tissue of the forearm or abdomen of healthy and diabetic volunteers was attempted, the readings were about 10% lower than blood glucose concentrations, but good correlation between them was observed in the range of 60 to 400 mg/dl. Perfect glycaemic control was established by infusing insulin either intravenously or subcutaneously in response to measured glucose concentrations on a moment-to-moment basis in diabetics for a period of several days. These results might indicate the feasibility of long-term glycaemic control in ambulatory diabetic patients with a wearable closed-loop glycaemic control system.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6477542

Citation

Shichiri, M, et al. "The Development of Wearable-type Artificial Endocrine Pancreas and Its Usefulness in Glycaemic Control of Human Diabetes Mellitus." Biomedica Biochimica Acta, vol. 43, no. 5, 1984, pp. 561-8.
Shichiri M, Kawamori R, Hakui N, et al. The development of wearable-type artificial endocrine pancreas and its usefulness in glycaemic control of human diabetes mellitus. Biomed Biochim Acta. 1984;43(5):561-8.
Shichiri, M., Kawamori, R., Hakui, N., Asakawa, N., Yamasaki, Y., & Abe, H. (1984). The development of wearable-type artificial endocrine pancreas and its usefulness in glycaemic control of human diabetes mellitus. Biomedica Biochimica Acta, 43(5), 561-8.
Shichiri M, et al. The Development of Wearable-type Artificial Endocrine Pancreas and Its Usefulness in Glycaemic Control of Human Diabetes Mellitus. Biomed Biochim Acta. 1984;43(5):561-8. PubMed PMID: 6477542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The development of wearable-type artificial endocrine pancreas and its usefulness in glycaemic control of human diabetes mellitus. AU - Shichiri,M, AU - Kawamori,R, AU - Hakui,N, AU - Asakawa,N, AU - Yamasaki,Y, AU - Abe,H, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 561 EP - 8 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 43 IS - 5 N2 - We have succeeded in miniaturizing a glucose monitoring system into a needle-type which preserves the characteristics suitable for application in a wearable closed-loop control system. The wearable artificial endocrine pancreas (12 X 15 X 6 cm, 400 g) consists of the sensor, a microcomputer which calculates the insulin and glucagon infusion rates and of a 2-syringe driving system. The device succeeded in controlling glycaemia perfectly in depancreatized dogs for a period of 3 days, and with replacement of subcutaneously inserted sensor for up to 7 days. When glucose monitoring by a needle-type glucose sensor inserted into subcutaneous tissue of the forearm or abdomen of healthy and diabetic volunteers was attempted, the readings were about 10% lower than blood glucose concentrations, but good correlation between them was observed in the range of 60 to 400 mg/dl. Perfect glycaemic control was established by infusing insulin either intravenously or subcutaneously in response to measured glucose concentrations on a moment-to-moment basis in diabetics for a period of several days. These results might indicate the feasibility of long-term glycaemic control in ambulatory diabetic patients with a wearable closed-loop glycaemic control system. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/6477542/The_development_of_wearable_type_artificial_endocrine_pancreas_and_its_usefulness_in_glycaemic_control_of_human_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -