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Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell.
Biomed Biochim Acta. 1984; 43(5):577-84.BB

Abstract

A modification of a Clark-type glucose electrode which proved suitable for implantation and for connection to a glucose-controlled insulin infusion system is presented. It involves a third hydrophilic or perforated hydrophobic membrane and is based upon measurement of the H2O2 generated by the glucose oxidase reaction. The linear calibration range is greater than 40 mmol/l glucose concentration with a tau 95 of 360 or 600 s, respectively (different sandwich prototypes). There is reliable glucose-dependent sensor output up to a 15 mmol/l concentration when the pO2 is as low as 2 to 5 kPa as monitored in subcutaneous tissue. One prototype series of the sensor was employed for paracorporal (ex vivo) glucose monitoring in undiluted blood and for insulin infusions in diabetic dogs, which were feedback-controlled by the sensor's output. Another prototype was designed and applied for subcutaneous implantation. Tissue glucose concentration amounts to 30 to 50% of the simultaneously measured blood plasma glucose level which is mirrored in a total lag time (i.e. tau 95 of sensor and physiological delay in interstitial fluid) of 15-20 min. The glucose sensor presented provides a transient step towards a long-term functioning implantable instrument.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6477543

Citation

Abel, P, et al. "Experience With an Implantable Glucose Sensor as a Prerequisite of an Artificial Beta Cell." Biomedica Biochimica Acta, vol. 43, no. 5, 1984, pp. 577-84.
Abel P, Müller A, Fischer U. Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell. Biomed Biochim Acta. 1984;43(5):577-84.
Abel, P., Müller, A., & Fischer, U. (1984). Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell. Biomedica Biochimica Acta, 43(5), 577-84.
Abel P, Müller A, Fischer U. Experience With an Implantable Glucose Sensor as a Prerequisite of an Artificial Beta Cell. Biomed Biochim Acta. 1984;43(5):577-84. PubMed PMID: 6477543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell. AU - Abel,P, AU - Müller,A, AU - Fischer,U, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 577 EP - 84 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 43 IS - 5 N2 - A modification of a Clark-type glucose electrode which proved suitable for implantation and for connection to a glucose-controlled insulin infusion system is presented. It involves a third hydrophilic or perforated hydrophobic membrane and is based upon measurement of the H2O2 generated by the glucose oxidase reaction. The linear calibration range is greater than 40 mmol/l glucose concentration with a tau 95 of 360 or 600 s, respectively (different sandwich prototypes). There is reliable glucose-dependent sensor output up to a 15 mmol/l concentration when the pO2 is as low as 2 to 5 kPa as monitored in subcutaneous tissue. One prototype series of the sensor was employed for paracorporal (ex vivo) glucose monitoring in undiluted blood and for insulin infusions in diabetic dogs, which were feedback-controlled by the sensor's output. Another prototype was designed and applied for subcutaneous implantation. Tissue glucose concentration amounts to 30 to 50% of the simultaneously measured blood plasma glucose level which is mirrored in a total lag time (i.e. tau 95 of sensor and physiological delay in interstitial fluid) of 15-20 min. The glucose sensor presented provides a transient step towards a long-term functioning implantable instrument. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/6477543/Experience_with_an_implantable_glucose_sensor_as_a_prerequisite_of_an_artificial_beta_cell_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6477543 DB - PRIME DP - Unbound Medicine ER -