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Warfarin sodium: steady-state plasma levels and patient age.
Clin Exp Pharmacol Physiol. 1978 Mar-Apr; 5(2):143-9.CE

Abstract

1. Steady-state plasma levels of warfarin were measured in thirty-nine ambulatory patients attending a haematology clinic. 2. Plasma concentrations, plasma clearance, and prothrombin ratio showed no significant differences when patients below 65 years of age were compared with those above 65 years. The mean daily maintenance dose of warfarin required was marginally greater for the younger patients but the difference was not statistically significant (P = 0.10). 3. A significant relationship was found between the daily maintenance dose of warfarin required by all patients and their mean steady-state plasma level (r = 0.5667, P less than 0.001). 4. For one elderly hospitalized patient it was apparent that there was a marked depression of the vitamin K-dependent clotting factor synthesis by warfarin which was associated with a hypoprothrombinaemic response.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

648034

Citation

Hotraphinyo, K, et al. "Warfarin Sodium: Steady-state Plasma Levels and Patient Age." Clinical and Experimental Pharmacology & Physiology, vol. 5, no. 2, 1978, pp. 143-9.
Hotraphinyo K, Triggs EJ, Maybloom B, et al. Warfarin sodium: steady-state plasma levels and patient age. Clin Exp Pharmacol Physiol. 1978;5(2):143-9.
Hotraphinyo, K., Triggs, E. J., Maybloom, B., & Maclaine-Cross, A. (1978). Warfarin sodium: steady-state plasma levels and patient age. Clinical and Experimental Pharmacology & Physiology, 5(2), 143-9.
Hotraphinyo K, et al. Warfarin Sodium: Steady-state Plasma Levels and Patient Age. Clin Exp Pharmacol Physiol. 1978 Mar-Apr;5(2):143-9. PubMed PMID: 648034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Warfarin sodium: steady-state plasma levels and patient age. AU - Hotraphinyo,K, AU - Triggs,E J, AU - Maybloom,B, AU - Maclaine-Cross,A, PY - 1978/3/1/pubmed PY - 1978/3/1/medline PY - 1978/3/1/entrez SP - 143 EP - 9 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 5 IS - 2 N2 - 1. Steady-state plasma levels of warfarin were measured in thirty-nine ambulatory patients attending a haematology clinic. 2. Plasma concentrations, plasma clearance, and prothrombin ratio showed no significant differences when patients below 65 years of age were compared with those above 65 years. The mean daily maintenance dose of warfarin required was marginally greater for the younger patients but the difference was not statistically significant (P = 0.10). 3. A significant relationship was found between the daily maintenance dose of warfarin required by all patients and their mean steady-state plasma level (r = 0.5667, P less than 0.001). 4. For one elderly hospitalized patient it was apparent that there was a marked depression of the vitamin K-dependent clotting factor synthesis by warfarin which was associated with a hypoprothrombinaemic response. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/648034/Warfarin_sodium:_steady_state_plasma_levels_and_patient_age_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0305-1870&date=1978&volume=5&issue=2&spage=143 DB - PRIME DP - Unbound Medicine ER -