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The association of histologic gastritis with gastroesophageal reflux and delayed gastric emptying.
J Clin Gastroenterol 1984; 6(4):301-9JC

Abstract

The aims of this study were to: 1) investigate the incidence of histologic gastritis in patients with gastroesophageal reflux (GER); 2) ascertain if gastritis in GER patients could be correlated with impaired gastric emptying; and 3) determine if the presence of histologic antral gastritis correlated with other parameters of esophageal and gastric function. Twenty-three GER patients, mean age 53.3 years (range 28-68 years) with subjective and objective evidence for GER; and 20 normal subjects (13 males and seven females), mean age 28.7 years (range 19-46 years), underwent upper gastrointestinal endoscopy. Antral biopsies obtained from the greater curvature were graded as: 0 = normal; 1 = chronic gastritis; 2 = chronic active gastritis; and 3 = chronic atrophic gastritis. All patients underwent a gastric emptying study using an isotope-labeled semisolid meal. Eighteen of the 23 GER patients (78%) had histologic gastritis compared to two (10%) of the normals. No subject had endoscopic evidence of gastritis. Gradings of histologic gastritis were significantly (p less than 0.05) correlated with delayed gastric emptying. Twelve GER patients had severe gastritis (grades 2 or 3) and their gastric emptying, 79.7% +/- 5.8 (mean +/- S.E.M.) retention of isotope at 90 minutes after the meal, was significantly slower (p less than 0.01) than the 11 GER patients with either grade 0 or 1 gastritis, 56.1% +/- 5.9 retention, or the normal subjects, 51.8% +/- 1.7. We conclude that: 1) histologic gastritis is associated with GER disease; and 2) slowing of gastric emptying can be significantly correlated with increased severity of histologic gastritis in GER patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6481113

Citation

Fink, S M., et al. "The Association of Histologic Gastritis With Gastroesophageal Reflux and Delayed Gastric Emptying." Journal of Clinical Gastroenterology, vol. 6, no. 4, 1984, pp. 301-9.
Fink SM, Barwick KW, DeLuca V, et al. The association of histologic gastritis with gastroesophageal reflux and delayed gastric emptying. J Clin Gastroenterol. 1984;6(4):301-9.
Fink, S. M., Barwick, K. W., DeLuca, V., Sanders, F. J., Kandathil, M., & McCallum, R. W. (1984). The association of histologic gastritis with gastroesophageal reflux and delayed gastric emptying. Journal of Clinical Gastroenterology, 6(4), pp. 301-9.
Fink SM, et al. The Association of Histologic Gastritis With Gastroesophageal Reflux and Delayed Gastric Emptying. J Clin Gastroenterol. 1984;6(4):301-9. PubMed PMID: 6481113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of histologic gastritis with gastroesophageal reflux and delayed gastric emptying. AU - Fink,S M, AU - Barwick,K W, AU - DeLuca,V, AU - Sanders,F J, AU - Kandathil,M, AU - McCallum,R W, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 301 EP - 9 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 6 IS - 4 N2 - The aims of this study were to: 1) investigate the incidence of histologic gastritis in patients with gastroesophageal reflux (GER); 2) ascertain if gastritis in GER patients could be correlated with impaired gastric emptying; and 3) determine if the presence of histologic antral gastritis correlated with other parameters of esophageal and gastric function. Twenty-three GER patients, mean age 53.3 years (range 28-68 years) with subjective and objective evidence for GER; and 20 normal subjects (13 males and seven females), mean age 28.7 years (range 19-46 years), underwent upper gastrointestinal endoscopy. Antral biopsies obtained from the greater curvature were graded as: 0 = normal; 1 = chronic gastritis; 2 = chronic active gastritis; and 3 = chronic atrophic gastritis. All patients underwent a gastric emptying study using an isotope-labeled semisolid meal. Eighteen of the 23 GER patients (78%) had histologic gastritis compared to two (10%) of the normals. No subject had endoscopic evidence of gastritis. Gradings of histologic gastritis were significantly (p less than 0.05) correlated with delayed gastric emptying. Twelve GER patients had severe gastritis (grades 2 or 3) and their gastric emptying, 79.7% +/- 5.8 (mean +/- S.E.M.) retention of isotope at 90 minutes after the meal, was significantly slower (p less than 0.01) than the 11 GER patients with either grade 0 or 1 gastritis, 56.1% +/- 5.9 retention, or the normal subjects, 51.8% +/- 1.7. We conclude that: 1) histologic gastritis is associated with GER disease; and 2) slowing of gastric emptying can be significantly correlated with increased severity of histologic gastritis in GER patients. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/6481113/The_association_of_histologic_gastritis_with_gastroesophageal_reflux_and_delayed_gastric_emptying_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -