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Effect of erythrocyte transfusion on the circulation of Guérin carcinoma-bearing rats.
Acta Physiol Hung. 1984; 64(1):9-17.AP

Abstract

In Guérin carcinoma-bearing rats during tumour growth cardiac output and blood flow to several organs were increased whereas TPR, vascular resistance of some regions and haematocrit gradually decreased. In response to erythrocyte transfusion the anaemia of tumour-bearing rats was considerably improved or corrected, however, the parameters for systemic and regional circulation were only partially restored. We presume that the circulatory "hyperkinesis" of tumour-bearing rats is partly due to the anaemia but also an unknown factor must be considered. The blood perfusion of the Guérin carcinoma was not affected by the erythrocyte transfusion thus it is feasible that the tumour vasculature is maximally dilated even with a normal haematocrit of the host.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6485821

Citation

Takács, L, et al. "Effect of Erythrocyte Transfusion On the Circulation of Guérin Carcinoma-bearing Rats." Acta Physiologica Hungarica, vol. 64, no. 1, 1984, pp. 9-17.
Takács L, Albert K, Karai A, et al. Effect of erythrocyte transfusion on the circulation of Guérin carcinoma-bearing rats. Acta Physiol Hung. 1984;64(1):9-17.
Takács, L., Albert, K., Karai, A., & Szarvassy, I. (1984). Effect of erythrocyte transfusion on the circulation of Guérin carcinoma-bearing rats. Acta Physiologica Hungarica, 64(1), 9-17.
Takács L, et al. Effect of Erythrocyte Transfusion On the Circulation of Guérin Carcinoma-bearing Rats. Acta Physiol Hung. 1984;64(1):9-17. PubMed PMID: 6485821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of erythrocyte transfusion on the circulation of Guérin carcinoma-bearing rats. AU - Takács,L, AU - Albert,K, AU - Karai,A, AU - Szarvassy,I, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 9 EP - 17 JF - Acta physiologica Hungarica JO - Acta Physiol Hung VL - 64 IS - 1 N2 - In Guérin carcinoma-bearing rats during tumour growth cardiac output and blood flow to several organs were increased whereas TPR, vascular resistance of some regions and haematocrit gradually decreased. In response to erythrocyte transfusion the anaemia of tumour-bearing rats was considerably improved or corrected, however, the parameters for systemic and regional circulation were only partially restored. We presume that the circulatory "hyperkinesis" of tumour-bearing rats is partly due to the anaemia but also an unknown factor must be considered. The blood perfusion of the Guérin carcinoma was not affected by the erythrocyte transfusion thus it is feasible that the tumour vasculature is maximally dilated even with a normal haematocrit of the host. SN - 0231-424X UR - https://www.unboundmedicine.com/medline/citation/6485821/Effect_of_erythrocyte_transfusion_on_the_circulation_of_Guérin_carcinoma_bearing_rats_ L2 - https://medlineplus.gov/bloodtransfusionanddonation.html DB - PRIME DP - Unbound Medicine ER -