Tags

Type your tag names separated by a space and hit enter

Inter- and intracompartmental osmotic gradients within the rat cochlea.
Am J Physiol. 1984 Oct; 247(4 Pt 2):F602-6.AJ

Abstract

The osmolality and the electrochemical composition of the endolymph, a potassium-rich positively polarized extracellular fluid in the cochlea, was studied in the rat. Endolymph of each cochlear turn was hyperosmotic to perilymph and plasma. Osmolalities (mosmol/kg H2O) were 329 +/- 2.9 (mean +/- SE) (n = 13) in basal turn endolymph, 322 +/- 2.7 (n = 9) in middle turn endolymph, 317 +/- 5.2 (n = 3) in apical turn endolymph, 289 +/- 3.1 (n = 14) in perilymph of the scala vestibuli, and 298 +/- 1.8 (n = 7) in plasma. Moreover, differences in osmolality and electrochemical composition of endolymph, involving resting potential and K and Cl concentrations, were observed between the basal and the middle cochlear turns, suggesting the presence of an electrical and osmotic gradient within endolymph, declining from the base to the apex of the cochlea. The active potassium transport into endolymph, located presumably in the stria vascularis, could account for both the internal and external osmotic gradients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6496688

Citation

Sterkers, O, et al. "Inter- and Intracompartmental Osmotic Gradients Within the Rat Cochlea." The American Journal of Physiology, vol. 247, no. 4 Pt 2, 1984, pp. F602-6.
Sterkers O, Ferrary E, Amiel C. Inter- and intracompartmental osmotic gradients within the rat cochlea. Am J Physiol. 1984;247(4 Pt 2):F602-6.
Sterkers, O., Ferrary, E., & Amiel, C. (1984). Inter- and intracompartmental osmotic gradients within the rat cochlea. The American Journal of Physiology, 247(4 Pt 2), F602-6.
Sterkers O, Ferrary E, Amiel C. Inter- and Intracompartmental Osmotic Gradients Within the Rat Cochlea. Am J Physiol. 1984;247(4 Pt 2):F602-6. PubMed PMID: 6496688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inter- and intracompartmental osmotic gradients within the rat cochlea. AU - Sterkers,O, AU - Ferrary,E, AU - Amiel,C, PY - 1984/10/1/pubmed PY - 1984/10/1/medline PY - 1984/10/1/entrez SP - F602 EP - 6 JF - The American journal of physiology JO - Am. J. Physiol. VL - 247 IS - 4 Pt 2 N2 - The osmolality and the electrochemical composition of the endolymph, a potassium-rich positively polarized extracellular fluid in the cochlea, was studied in the rat. Endolymph of each cochlear turn was hyperosmotic to perilymph and plasma. Osmolalities (mosmol/kg H2O) were 329 +/- 2.9 (mean +/- SE) (n = 13) in basal turn endolymph, 322 +/- 2.7 (n = 9) in middle turn endolymph, 317 +/- 5.2 (n = 3) in apical turn endolymph, 289 +/- 3.1 (n = 14) in perilymph of the scala vestibuli, and 298 +/- 1.8 (n = 7) in plasma. Moreover, differences in osmolality and electrochemical composition of endolymph, involving resting potential and K and Cl concentrations, were observed between the basal and the middle cochlear turns, suggesting the presence of an electrical and osmotic gradient within endolymph, declining from the base to the apex of the cochlea. The active potassium transport into endolymph, located presumably in the stria vascularis, could account for both the internal and external osmotic gradients. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/6496688/Inter__and_intracompartmental_osmotic_gradients_within_the_rat_cochlea_ L2 - http://journals.physiology.org/doi/full/10.1152/ajprenal.1984.247.4.F602?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -