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Effects of cholinomimetic drugs on reptilian atrial muscles.
Methods Find Exp Clin Pharmacol. 1984 Jul; 6(7):379-87.MF

Abstract

The effects of some cholinomimetic drugs have been examined on isolated atria of rainbow lizards (Agama agama Linn.) and land tortoises (Kinixys spp. Linn.). Acetylcholine (ACh, 10(-8) - 5 X 10(-5) M) caused concentration-dependent, atropine-sensitive, negative chronotropic or inotropic responses in isolated spontaneously-beating right or electrically-driven left atria of rainbow lizards and land tortoises. This prototype cholinergic drug (ACh, 10(-8) 5 X 10(-5) M) also induced atropine-sensitive, concentration-related negative chronotropic or inotropic responses in isolated atrial muscles taken from guinea-pigs. Histamine (10(-8) - 5 X 10(-5) M) produced concentration-related positive chronotropic or inotropic responses in isolated spontaneously-beating right or electrically-driven left atria of rainbow lizards and guinea-pigs without significantly affecting (P greater than 0.05) the tortoise atria. 5-Hydroxytryptamine (5-HT, 10(-7) - 5 X 10(-5) M) induced concentration-dependent positive chronotropic or inotropic responses in isolated, spontaneously-beating right or electrically-driven left atria of rainbow lizards, tortoises and guinea-pigs. Nicotine (10(-8) - 5 X 10(-5) M) had no effect on the rate of beating of the lizard or tortoise isolated right atria, but caused concentration-dependent positive chronotropic responses in spontaneously-beating isolated right atria of the guinea-pig. Furthermore, nicotine (10(-8) - 5 X 10(-5) M) had no effect on contractile tension of isolated, electrically-driven left atria of the tortoise; it induced a biphasic inotropic response in driven left atria of the rainbow lizard and produced a concentration-related positive inotropic response in electrically-driven isolated left atria of the guinea-pig.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6503473

Citation

Ojewole, J A., and K I. Akinwande. "Effects of Cholinomimetic Drugs On Reptilian Atrial Muscles." Methods and Findings in Experimental and Clinical Pharmacology, vol. 6, no. 7, 1984, pp. 379-87.
Ojewole JA, Akinwande KI. Effects of cholinomimetic drugs on reptilian atrial muscles. Methods Find Exp Clin Pharmacol. 1984;6(7):379-87.
Ojewole, J. A., & Akinwande, K. I. (1984). Effects of cholinomimetic drugs on reptilian atrial muscles. Methods and Findings in Experimental and Clinical Pharmacology, 6(7), 379-87.
Ojewole JA, Akinwande KI. Effects of Cholinomimetic Drugs On Reptilian Atrial Muscles. Methods Find Exp Clin Pharmacol. 1984;6(7):379-87. PubMed PMID: 6503473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cholinomimetic drugs on reptilian atrial muscles. AU - Ojewole,J A, AU - Akinwande,K I, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 379 EP - 87 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 6 IS - 7 N2 - The effects of some cholinomimetic drugs have been examined on isolated atria of rainbow lizards (Agama agama Linn.) and land tortoises (Kinixys spp. Linn.). Acetylcholine (ACh, 10(-8) - 5 X 10(-5) M) caused concentration-dependent, atropine-sensitive, negative chronotropic or inotropic responses in isolated spontaneously-beating right or electrically-driven left atria of rainbow lizards and land tortoises. This prototype cholinergic drug (ACh, 10(-8) 5 X 10(-5) M) also induced atropine-sensitive, concentration-related negative chronotropic or inotropic responses in isolated atrial muscles taken from guinea-pigs. Histamine (10(-8) - 5 X 10(-5) M) produced concentration-related positive chronotropic or inotropic responses in isolated spontaneously-beating right or electrically-driven left atria of rainbow lizards and guinea-pigs without significantly affecting (P greater than 0.05) the tortoise atria. 5-Hydroxytryptamine (5-HT, 10(-7) - 5 X 10(-5) M) induced concentration-dependent positive chronotropic or inotropic responses in isolated, spontaneously-beating right or electrically-driven left atria of rainbow lizards, tortoises and guinea-pigs. Nicotine (10(-8) - 5 X 10(-5) M) had no effect on the rate of beating of the lizard or tortoise isolated right atria, but caused concentration-dependent positive chronotropic responses in spontaneously-beating isolated right atria of the guinea-pig. Furthermore, nicotine (10(-8) - 5 X 10(-5) M) had no effect on contractile tension of isolated, electrically-driven left atria of the tortoise; it induced a biphasic inotropic response in driven left atria of the rainbow lizard and produced a concentration-related positive inotropic response in electrically-driven isolated left atria of the guinea-pig.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/6503473/Effects_of_cholinomimetic_drugs_on_reptilian_atrial_muscles_ DB - PRIME DP - Unbound Medicine ER -