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Cerebral blood flow under hypobaric conditions: effects of pentoxifylline ('Trental' 400).
Pharmatherapeutica. 1984; 4(1):1-5.P

Abstract

A single-blind, crossover study was carried out in 9 healthy subjects to investigate the effect of a single dose of 2 tablets of 400 mg pentoxifylline ('Trental' 400) or placebo on cerebral blood flow, cerebral perfusion quotient and mental functions under experimental hypobaric conditions. Subjects were exposed in a low pressure chamber to simulated atmospheric pressures at sea level, 4000 and 7000 metres, and tests were performed 2 hours after intake of the dose, using 99m technetium brain scintigraphy and psychometric tests, to assess acutely induced impairment of cerebral function. After placebo, cerebral blood flow was decreased, especially at the 7000 metre level, whereas there was significantly less decrease after pentoxifylline. The perfusion quotient was normal throughout the pentoxifylline period but was outside the normal range in 8 of the 9 subjects after placebo. Psychometric testing showed better performance by the subjects after drug than after placebo intake. The results suggest that pentoxifylline may protect cerebral blood flow, nutrition and function under impaired supply conditions.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6504944

Citation

Koppenhagen, K. "Cerebral Blood Flow Under Hypobaric Conditions: Effects of Pentoxifylline ('Trental' 400)." Pharmatherapeutica, vol. 4, no. 1, 1984, pp. 1-5.
Koppenhagen K. Cerebral blood flow under hypobaric conditions: effects of pentoxifylline ('Trental' 400). Pharmatherapeutica. 1984;4(1):1-5.
Koppenhagen, K. (1984). Cerebral blood flow under hypobaric conditions: effects of pentoxifylline ('Trental' 400). Pharmatherapeutica, 4(1), 1-5.
Koppenhagen K. Cerebral Blood Flow Under Hypobaric Conditions: Effects of Pentoxifylline ('Trental' 400). Pharmatherapeutica. 1984;4(1):1-5. PubMed PMID: 6504944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral blood flow under hypobaric conditions: effects of pentoxifylline ('Trental' 400). A1 - Koppenhagen,K, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 1 EP - 5 JF - Pharmatherapeutica JO - Pharmatherapeutica VL - 4 IS - 1 N2 - A single-blind, crossover study was carried out in 9 healthy subjects to investigate the effect of a single dose of 2 tablets of 400 mg pentoxifylline ('Trental' 400) or placebo on cerebral blood flow, cerebral perfusion quotient and mental functions under experimental hypobaric conditions. Subjects were exposed in a low pressure chamber to simulated atmospheric pressures at sea level, 4000 and 7000 metres, and tests were performed 2 hours after intake of the dose, using 99m technetium brain scintigraphy and psychometric tests, to assess acutely induced impairment of cerebral function. After placebo, cerebral blood flow was decreased, especially at the 7000 metre level, whereas there was significantly less decrease after pentoxifylline. The perfusion quotient was normal throughout the pentoxifylline period but was outside the normal range in 8 of the 9 subjects after placebo. Psychometric testing showed better performance by the subjects after drug than after placebo intake. The results suggest that pentoxifylline may protect cerebral blood flow, nutrition and function under impaired supply conditions. SN - 0308-051X UR - https://www.unboundmedicine.com/medline/citation/6504944/Cerebral_blood_flow_under_hypobaric_conditions:_effects_of_pentoxifylline__'Trental'_400__ DB - PRIME DP - Unbound Medicine ER -