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The Royal College of General Practitioners' Oral Contraception Study: some recent observations.
Clin Obstet Gynaecol. 1984 Dec; 11(3):759-86.CO

Abstract

The Royal College of General Practitioners' Oral Contraception Study is a continuing cohort survey of the effects of oral contraceptives on the health of users. Neurotic depression is associated with the oestrogen content of combined oral contraceptives, but the risk is small in general, and there is no excess risk associated with oestrogen doses of 35 micrograms or less. It now appears likely that, in the long-term, oral contraceptives are not associated with any increased risk of gallbladder disease, although there is an acceleration of the disease in those women susceptible to it. The progestogen activity of combined oral contraceptives is associated with an increased risk of hypertension and arterial disease. Duration of use no longer seems to influence the occurrence of the latter. Cigarette smoking by oral contraceptive users is the predominant associated risk factor for the occurrence of arterial diseases. Non-smokers using low-progestogen-dose brands may safely use oral contraceptives, probably up to the age of 45 years. In the author's opinion, there is no convincing evidence that oral contraceptive use increases the risk of breast cancer. The evidence for an association with cervical cancer is firmer, but, if confirmed, is unlikely to affect more than one in 3000 users a year. Increased safety in the use of oral contraceptives in future is likely to be achieved through the use of tests which will allow the adjustment of dose to be made to each patient's particular requirements.

Authors

Kay CR
No affiliation info available

MeSH

AdolescentAdultAge FactorsBreast NeoplasmsContraceptives, OralDepressionFemaleGallbladder DiseasesHumansMiddle AgedOvarian NeoplasmsProgesterone CongenersSmokingSuicide, AttemptedTime FactorsUterine Cervical NeoplasmsVascular Diseases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6509858

Citation

Kay, C R.. "The Royal College of General Practitioners' Oral Contraception Study: some Recent Observations." Clinics in Obstetrics and Gynaecology, vol. 11, no. 3, 1984, pp. 759-86.
Kay CR. The Royal College of General Practitioners' Oral Contraception Study: some recent observations. Clin Obstet Gynaecol. 1984;11(3):759-86.
Kay, C. R. (1984). The Royal College of General Practitioners' Oral Contraception Study: some recent observations. Clinics in Obstetrics and Gynaecology, 11(3), 759-86.
Kay CR. The Royal College of General Practitioners' Oral Contraception Study: some Recent Observations. Clin Obstet Gynaecol. 1984;11(3):759-86. PubMed PMID: 6509858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Royal College of General Practitioners' Oral Contraception Study: some recent observations. A1 - Kay,C R, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez KW - Arterial Occlusive Diseases KW - Behavior KW - Biliary Tract Diseases KW - Biology KW - Breast Cancer KW - Cancer KW - Cardiovascular Effects KW - Cervical Cancer KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Depression KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Gallbladder Diseases KW - Mental Disorders KW - Neoplasms KW - Northern Europe KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Sampling Studies KW - Smoking KW - Social Behavior KW - Studies KW - Surveys KW - United Kingdom KW - Vascular Diseases SP - 759 EP - 86 JF - Clinics in obstetrics and gynaecology JO - Clin Obstet Gynaecol VL - 11 IS - 3 N2 - The Royal College of General Practitioners' Oral Contraception Study is a continuing cohort survey of the effects of oral contraceptives on the health of users. Neurotic depression is associated with the oestrogen content of combined oral contraceptives, but the risk is small in general, and there is no excess risk associated with oestrogen doses of 35 micrograms or less. It now appears likely that, in the long-term, oral contraceptives are not associated with any increased risk of gallbladder disease, although there is an acceleration of the disease in those women susceptible to it. The progestogen activity of combined oral contraceptives is associated with an increased risk of hypertension and arterial disease. Duration of use no longer seems to influence the occurrence of the latter. Cigarette smoking by oral contraceptive users is the predominant associated risk factor for the occurrence of arterial diseases. Non-smokers using low-progestogen-dose brands may safely use oral contraceptives, probably up to the age of 45 years. In the author's opinion, there is no convincing evidence that oral contraceptive use increases the risk of breast cancer. The evidence for an association with cervical cancer is firmer, but, if confirmed, is unlikely to affect more than one in 3000 users a year. Increased safety in the use of oral contraceptives in future is likely to be achieved through the use of tests which will allow the adjustment of dose to be made to each patient's particular requirements. SN - 0306-3356 UR - https://www.unboundmedicine.com/medline/citation/6509858/The_Royal_College_of_General_Practitioners'_Oral_Contraception_Study:_some_recent_observations_ DB - PRIME DP - Unbound Medicine ER -