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Early sensory-motor development and prenatal exposure to lead.
Neurobehav Toxicol Teratol. 1984 Sep-Oct; 6(5):387-402.NT

Abstract

As part of a longitudinal study of the early developmental effects of exposure to lead, we administered the Bayley Scales of Infant Development at age 6 months to infants classified into three groups based on their umbilical cord blood lead levels ("low": mean = 1.8 micrograms/dl; "mid": mean = 6.5 micrograms/dl; "high": mean = 14.6 micrograms/dl). No infant had a cord blood lead level greater than 30 micrograms/dl, the level currently regarded as the upper limit of "normal" for young children. Multiple regression analyses indicated that high cord blood levels were associated with lower covariance-adjusted scores on the Mental Development Index. Scores on the Psychomotor Development Index were not significantly related to cord blood lead level. The level of lead in blood at 6 months of age was not associated with scores on either the Mental or Psychomotor Development Index. These data are compatible with the hypothesis that low levels of lead delivered transplacentally are toxic to infants.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6514103

Citation

Bellinger, D C., et al. "Early Sensory-motor Development and Prenatal Exposure to Lead." Neurobehavioral Toxicology and Teratology, vol. 6, no. 5, 1984, pp. 387-402.
Bellinger DC, Needleman HL, Leviton A, et al. Early sensory-motor development and prenatal exposure to lead. Neurobehav Toxicol Teratol. 1984;6(5):387-402.
Bellinger, D. C., Needleman, H. L., Leviton, A., Waternaux, C., Rabinowitz, M. B., & Nichols, M. L. (1984). Early sensory-motor development and prenatal exposure to lead. Neurobehavioral Toxicology and Teratology, 6(5), 387-402.
Bellinger DC, et al. Early Sensory-motor Development and Prenatal Exposure to Lead. Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):387-402. PubMed PMID: 6514103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early sensory-motor development and prenatal exposure to lead. AU - Bellinger,D C, AU - Needleman,H L, AU - Leviton,A, AU - Waternaux,C, AU - Rabinowitz,M B, AU - Nichols,M L, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 387 EP - 402 JF - Neurobehavioral toxicology and teratology JO - Neurobehav Toxicol Teratol VL - 6 IS - 5 N2 - As part of a longitudinal study of the early developmental effects of exposure to lead, we administered the Bayley Scales of Infant Development at age 6 months to infants classified into three groups based on their umbilical cord blood lead levels ("low": mean = 1.8 micrograms/dl; "mid": mean = 6.5 micrograms/dl; "high": mean = 14.6 micrograms/dl). No infant had a cord blood lead level greater than 30 micrograms/dl, the level currently regarded as the upper limit of "normal" for young children. Multiple regression analyses indicated that high cord blood levels were associated with lower covariance-adjusted scores on the Mental Development Index. Scores on the Psychomotor Development Index were not significantly related to cord blood lead level. The level of lead in blood at 6 months of age was not associated with scores on either the Mental or Psychomotor Development Index. These data are compatible with the hypothesis that low levels of lead delivered transplacentally are toxic to infants. SN - 0275-1380 UR - https://www.unboundmedicine.com/medline/citation/6514103/Early_sensory_motor_development_and_prenatal_exposure_to_lead_ L2 - https://medlineplus.gov/toddlerdevelopment.html DB - PRIME DP - Unbound Medicine ER -