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Platelet aggregability, disaggregability and serotonin uptake in migraine.
Cephalalgia. 1984 Dec; 4(4):221-5.C

Abstract

Several disturbances in platelet function have been reported in migraineurs including serotonin (5-HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5-HT uptake revealed normal Km, increased Vmax values and lower imipramine inhibition in migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6518502

Citation

Kruglak, L, et al. "Platelet Aggregability, Disaggregability and Serotonin Uptake in Migraine." Cephalalgia : an International Journal of Headache, vol. 4, no. 4, 1984, pp. 221-5.
Kruglak L, Nathan I, Korczyn AD, et al. Platelet aggregability, disaggregability and serotonin uptake in migraine. Cephalalgia. 1984;4(4):221-5.
Kruglak, L., Nathan, I., Korczyn, A. D., Zolotov, Z., Berginer, V., & Dvilansky, A. (1984). Platelet aggregability, disaggregability and serotonin uptake in migraine. Cephalalgia : an International Journal of Headache, 4(4), 221-5.
Kruglak L, et al. Platelet Aggregability, Disaggregability and Serotonin Uptake in Migraine. Cephalalgia. 1984;4(4):221-5. PubMed PMID: 6518502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet aggregability, disaggregability and serotonin uptake in migraine. AU - Kruglak,L, AU - Nathan,I, AU - Korczyn,A D, AU - Zolotov,Z, AU - Berginer,V, AU - Dvilansky,A, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 221 EP - 5 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 4 IS - 4 N2 - Several disturbances in platelet function have been reported in migraineurs including serotonin (5-HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5-HT uptake revealed normal Km, increased Vmax values and lower imipramine inhibition in migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/6518502/Platelet_aggregability_disaggregability_and_serotonin_uptake_in_migraine_ L2 - https://journals.sagepub.com/doi/10.1046/j.1468-2982.1984.0404221.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -