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Effects of the acute rising dose administration of chlorine dioxide, chlorate and chlorite to normal healthy adult male volunteers.
J Environ Pathol Toxicol Oncol. 1984 Jul; 5(4-5):215-28.JE

Abstract

Chlorine dioxide is under consideration for use as a water disinfectant alternative to chlorination in the United States. A rising dose tolerance study was undertaken to assess the relative safety and tolerance of acute administration of chlorine dioxide and its byproducts, chlorite and chlorate, to normal healthy adult male volunteers. In evaluation of an extensive battery of laboratory tests and vital signs, no adverse physiological effects were identified. This provided a data base upon which a controlled 5-month study trial of these substances in normal healthy volunteer subjects was designed.

Authors

Lubbers JR
No affiliation info available
Bianchine JR
No affiliation info available

MeSH

AdultBlood Chemical AnalysisChloratesChloridesChlorineChlorine CompoundsDisinfectionDose-Response Relationship, DrugHumansMaleOxidesTasteWater MicrobiologyWater Supply

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6520727

Citation

Lubbers, J R., and J R. Bianchine. "Effects of the Acute Rising Dose Administration of Chlorine Dioxide, Chlorate and Chlorite to Normal Healthy Adult Male Volunteers." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 5, no. 4-5, 1984, pp. 215-28.
Lubbers JR, Bianchine JR. Effects of the acute rising dose administration of chlorine dioxide, chlorate and chlorite to normal healthy adult male volunteers. J Environ Pathol Toxicol Oncol. 1984;5(4-5):215-28.
Lubbers, J. R., & Bianchine, J. R. (1984). Effects of the acute rising dose administration of chlorine dioxide, chlorate and chlorite to normal healthy adult male volunteers. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 5(4-5), 215-28.
Lubbers JR, Bianchine JR. Effects of the Acute Rising Dose Administration of Chlorine Dioxide, Chlorate and Chlorite to Normal Healthy Adult Male Volunteers. J Environ Pathol Toxicol Oncol. 1984;5(4-5):215-28. PubMed PMID: 6520727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the acute rising dose administration of chlorine dioxide, chlorate and chlorite to normal healthy adult male volunteers. AU - Lubbers,J R, AU - Bianchine,J R, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 215 EP - 28 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 5 IS - 4-5 N2 - Chlorine dioxide is under consideration for use as a water disinfectant alternative to chlorination in the United States. A rising dose tolerance study was undertaken to assess the relative safety and tolerance of acute administration of chlorine dioxide and its byproducts, chlorite and chlorate, to normal healthy adult male volunteers. In evaluation of an extensive battery of laboratory tests and vital signs, no adverse physiological effects were identified. This provided a data base upon which a controlled 5-month study trial of these substances in normal healthy volunteer subjects was designed. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/6520727/Effects_of_the_acute_rising_dose_administration_of_chlorine_dioxide_chlorate_and_chlorite_to_normal_healthy_adult_male_volunteers_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6520727 DB - PRIME DP - Unbound Medicine ER -