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The effects of chronic administration of chlorite to glucose-6-phosphate dehydrogenase deficient healthy adult male volunteers.
J Environ Pathol Toxicol Oncol. 1984 Jul; 5(4-5):239-42.JE

Abstract

Under controlled laboratory conditions, the safety of daily ingestion of 5 ppm chlorine dioxide, chlorite and chlorate by normal healthy adult males has been established. To determine the effect upon potentially susceptible individuals, a parallel chronic human investigation was undertaken. Study subjects were three healthy adult males deficient in glucose-6-phosphate dehydrogenase. These volunteers received 500 ml of sodium chlorite at a concentration of 5 ppm daily for twelve consecutive weeks; the subsequent observation period extended an additional eight weeks. Upon evaluation of an extensive battery of tests designed to measure the biochemical and physiological response to chlorite ingestion, no clinically significant changes were detected.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6520729

Citation

Lubbers, J R., et al. "The Effects of Chronic Administration of Chlorite to Glucose-6-phosphate Dehydrogenase Deficient Healthy Adult Male Volunteers." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 5, no. 4-5, 1984, pp. 239-42.
Lubbers JR, Chauhan S, Miller JK, et al. The effects of chronic administration of chlorite to glucose-6-phosphate dehydrogenase deficient healthy adult male volunteers. J Environ Pathol Toxicol Oncol. 1984;5(4-5):239-42.
Lubbers, J. R., Chauhan, S., Miller, J. K., & Bianchine, J. R. (1984). The effects of chronic administration of chlorite to glucose-6-phosphate dehydrogenase deficient healthy adult male volunteers. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 5(4-5), 239-42.
Lubbers JR, et al. The Effects of Chronic Administration of Chlorite to Glucose-6-phosphate Dehydrogenase Deficient Healthy Adult Male Volunteers. J Environ Pathol Toxicol Oncol. 1984;5(4-5):239-42. PubMed PMID: 6520729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of chronic administration of chlorite to glucose-6-phosphate dehydrogenase deficient healthy adult male volunteers. AU - Lubbers,J R, AU - Chauhan,S, AU - Miller,J K, AU - Bianchine,J R, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 239 EP - 42 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 5 IS - 4-5 N2 - Under controlled laboratory conditions, the safety of daily ingestion of 5 ppm chlorine dioxide, chlorite and chlorate by normal healthy adult males has been established. To determine the effect upon potentially susceptible individuals, a parallel chronic human investigation was undertaken. Study subjects were three healthy adult males deficient in glucose-6-phosphate dehydrogenase. These volunteers received 500 ml of sodium chlorite at a concentration of 5 ppm daily for twelve consecutive weeks; the subsequent observation period extended an additional eight weeks. Upon evaluation of an extensive battery of tests designed to measure the biochemical and physiological response to chlorite ingestion, no clinically significant changes were detected. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/6520729/The_effects_of_chronic_administration_of_chlorite_to_glucose_6_phosphate_dehydrogenase_deficient_healthy_adult_male_volunteers_ L2 - https://medlineplus.gov/g6pddeficiency.html DB - PRIME DP - Unbound Medicine ER -
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