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Basic ferritin content of red cells of patients with anemia and polycythemia vera.
Pathology. 1984 Oct; 16(4):419-23.P

Abstract

Basic ferritin content of red cells has been evaluated with a simplified assay in subjects with various erythroid disorders. In 39 patients with iron deficiency anemia, red cell ferritin was significantly reduced compared with that of normal individuals. Thirty percent of these patients had low normal red cell ferritin content and the MCV for this group was significantly higher than that of patients with reduced red cell ferritin. The mean red cell ferritin of 30 subjects with the anemia of chronic disease was significantly reduced and patients in this group with normal red cell ferritin had higher plasma ferritin levels. In 14 patients with polycythemia vera, the mean red cell ferritin was significantly reduced and showed a positive correlation with the hemoglobin level and percent transferrin saturation. The red cell ferritin content of 9 individuals with acquired immune hemolytic anemia and 10 with acquired sideroblastic anemia was significantly elevated and, in subjects with immune hemolysis, showed a positive correlation with the reticulocyte count. These findings suggest a lack of discriminatory function for red cell ferritin in iron deficiency anemia and anemia of chronic disease. Evaluation of this parameter in the individual patient should take into account the presence of reticulocytosis.

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Authors

Van der Weyden MB
No affiliation info available
Fong H
No affiliation info available
Hallam LJ
No affiliation info available
Breidahl MJ
No affiliation info available

MeSH

AnemiaAnemia, HemolyticAnemia, HypochromicAnemia, SideroblasticChronic DiseaseErythrocytesFerritinsHemoglobinsHumansIronPolycythemia VeraTransferrin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6522107

Citation

Van der Weyden, M B., et al. "Basic Ferritin Content of Red Cells of Patients With Anemia and Polycythemia Vera." Pathology, vol. 16, no. 4, 1984, pp. 419-23.
Van der Weyden MB, Fong H, Hallam LJ, et al. Basic ferritin content of red cells of patients with anemia and polycythemia vera. Pathology. 1984;16(4):419-23.
Van der Weyden, M. B., Fong, H., Hallam, L. J., & Breidahl, M. J. (1984). Basic ferritin content of red cells of patients with anemia and polycythemia vera. Pathology, 16(4), 419-23.
Van der Weyden MB, et al. Basic Ferritin Content of Red Cells of Patients With Anemia and Polycythemia Vera. Pathology. 1984;16(4):419-23. PubMed PMID: 6522107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basic ferritin content of red cells of patients with anemia and polycythemia vera. AU - Van der Weyden,M B, AU - Fong,H, AU - Hallam,L J, AU - Breidahl,M J, PY - 1984/10/1/pubmed PY - 1984/10/1/medline PY - 1984/10/1/entrez SP - 419 EP - 23 JF - Pathology JO - Pathology VL - 16 IS - 4 N2 - Basic ferritin content of red cells has been evaluated with a simplified assay in subjects with various erythroid disorders. In 39 patients with iron deficiency anemia, red cell ferritin was significantly reduced compared with that of normal individuals. Thirty percent of these patients had low normal red cell ferritin content and the MCV for this group was significantly higher than that of patients with reduced red cell ferritin. The mean red cell ferritin of 30 subjects with the anemia of chronic disease was significantly reduced and patients in this group with normal red cell ferritin had higher plasma ferritin levels. In 14 patients with polycythemia vera, the mean red cell ferritin was significantly reduced and showed a positive correlation with the hemoglobin level and percent transferrin saturation. The red cell ferritin content of 9 individuals with acquired immune hemolytic anemia and 10 with acquired sideroblastic anemia was significantly elevated and, in subjects with immune hemolysis, showed a positive correlation with the reticulocyte count. These findings suggest a lack of discriminatory function for red cell ferritin in iron deficiency anemia and anemia of chronic disease. Evaluation of this parameter in the individual patient should take into account the presence of reticulocytosis. SN - 0031-3025 UR - https://www.unboundmedicine.com/medline/citation/6522107/Basic_ferritin_content_of_red_cells_of_patients_with_anemia_and_polycythemia_vera_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6522107.ui DB - PRIME DP - Unbound Medicine ER -