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The freeze fracture technique in inner ear research.

Abstract

Freeze-fracture studies on the inner ear have been focused mainly on the normal structure of junctions sealing the endolymphatic compartment, the compartmentalization of the stria vascularis and the junctional stability of the hair cells towards adjacent supporting cells. The hair cells have a very tight type of zonulae occludenetes as compared with other non-sensory epithelia in the inner ear. In contrast to other epithelial cells, the mature hair cells are in most species lacking gap junctions. During embryonic development a loss of gap junctions is an early and significant feature of cells differentiating into future hair cells. The tight junctions in the secretory epithelia (stria vascularis in the cochlea and dark cells around vestibular organs) are morphologically mature before the onset of the ionic maturation of endolymph. Freeze-fracture studies on inner ear pathology are few. The structural alterations of tight junctions in the diseased inner ear are minimal. The functional significance of such small morphological derangements is not known.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6523069

Citation

Anniko, M, and R Wróblewski. "The Freeze Fracture Technique in Inner Ear Research." Scanning Electron Microscopy, 1984, pp. 2067-75.
Anniko M, Wróblewski R. The freeze fracture technique in inner ear research. Scan Electron Microsc. 1984.
Anniko, M., & Wróblewski, R. (1984). The freeze fracture technique in inner ear research. Scanning Electron Microscopy, (Pt 4), 2067-75.
Anniko M, Wróblewski R. The Freeze Fracture Technique in Inner Ear Research. Scan Electron Microsc. 1984;(Pt 4)2067-75. PubMed PMID: 6523069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The freeze fracture technique in inner ear research. AU - Anniko,M, AU - Wróblewski,R, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 2067 EP - 75 JF - Scanning electron microscopy JO - Scan Electron Microsc IS - Pt 4 N2 - Freeze-fracture studies on the inner ear have been focused mainly on the normal structure of junctions sealing the endolymphatic compartment, the compartmentalization of the stria vascularis and the junctional stability of the hair cells towards adjacent supporting cells. The hair cells have a very tight type of zonulae occludenetes as compared with other non-sensory epithelia in the inner ear. In contrast to other epithelial cells, the mature hair cells are in most species lacking gap junctions. During embryonic development a loss of gap junctions is an early and significant feature of cells differentiating into future hair cells. The tight junctions in the secretory epithelia (stria vascularis in the cochlea and dark cells around vestibular organs) are morphologically mature before the onset of the ionic maturation of endolymph. Freeze-fracture studies on inner ear pathology are few. The structural alterations of tight junctions in the diseased inner ear are minimal. The functional significance of such small morphological derangements is not known. SN - 0586-5581 UR - https://www.unboundmedicine.com/medline/citation/6523069/The_freeze_fracture_technique_in_inner_ear_research_ DB - PRIME DP - Unbound Medicine ER -