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Elevated serum vitamin B12 in cystic fibrosis.
Acta Paediatr Scand. 1984 Nov; 73(6):768-71.AP

Abstract

In 62 patients with cystic fibrosis the serum vitamin B12 concentration ranged from 160-2600 pmol/l with a mean of 1 105 pmol/l. Both vitamin B12-binding proteins in the serum, transcobalamin II and R-binders, carried increased amounts of vitamin B12, but showed relatively normal levels of unsaturated vitamin B12-binding capacity. This combination is rather typical for hepatic dysfunction, although the recurrent pulmonary infections might exert an upward effect on plasma R-binder concentration through increased turnover of myeloid cells. A significant positive correlation between transcobalamin II-vitamin B12 and serum alkaline phosphatase suggests that transcobalamin II-bound vitamin B12 might be an early indicator of focal biliary cirrhosis, which is known to occur in these patients.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6524365

Citation

Lindemans, J, et al. "Elevated Serum Vitamin B12 in Cystic Fibrosis." Acta Paediatrica Scandinavica, vol. 73, no. 6, 1984, pp. 768-71.
Lindemans J, Abels J, Neijens HJ, et al. Elevated serum vitamin B12 in cystic fibrosis. Acta Paediatr Scand. 1984;73(6):768-71.
Lindemans, J., Abels, J., Neijens, H. J., & Kerrebijn, K. F. (1984). Elevated serum vitamin B12 in cystic fibrosis. Acta Paediatrica Scandinavica, 73(6), 768-71.
Lindemans J, et al. Elevated Serum Vitamin B12 in Cystic Fibrosis. Acta Paediatr Scand. 1984;73(6):768-71. PubMed PMID: 6524365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum vitamin B12 in cystic fibrosis. AU - Lindemans,J, AU - Abels,J, AU - Neijens,H J, AU - Kerrebijn,K F, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 768 EP - 71 JF - Acta paediatrica Scandinavica JO - Acta Paediatr Scand VL - 73 IS - 6 N2 - In 62 patients with cystic fibrosis the serum vitamin B12 concentration ranged from 160-2600 pmol/l with a mean of 1 105 pmol/l. Both vitamin B12-binding proteins in the serum, transcobalamin II and R-binders, carried increased amounts of vitamin B12, but showed relatively normal levels of unsaturated vitamin B12-binding capacity. This combination is rather typical for hepatic dysfunction, although the recurrent pulmonary infections might exert an upward effect on plasma R-binder concentration through increased turnover of myeloid cells. A significant positive correlation between transcobalamin II-vitamin B12 and serum alkaline phosphatase suggests that transcobalamin II-bound vitamin B12 might be an early indicator of focal biliary cirrhosis, which is known to occur in these patients. SN - 0001-656X UR - https://www.unboundmedicine.com/medline/citation/6524365/Elevated_serum_vitamin_B12_in_cystic_fibrosis_ L2 - http://www.diseaseinfosearch.org/result/2071 DB - PRIME DP - Unbound Medicine ER -