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Purified chick embryo cell (PCEC) rabies vaccine for human use. Laboratory data.
Behring Inst Mitt. 1984 NovBI

Abstract

A new inactivated rabies vaccine (Purified Chick Embryo Cell vaccine) for use in humans has been developed. The FLURY-LEP C25 strain of rabies virus was adapted to propagate in primary chick embryo cell cultures. The antigen was purified and concentrated by continuous density gradient centrifugation and inactivated by Betapropiolactone. The PCEC-rabies vaccine was tested for innocuity, tolerability and protective capacity in a series of laboratory tests and compared with Human Diploid Cell Strain rabies vaccine (HDCSV) of similar antigenicity. The results of the laboratory tests indicated that this new vaccine was excellently tolerated and that its protective activity met the high standard of HDCS-vaccine, conditions which were imposed on the PCEC-vaccine before clinical trials in man were initiated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6525146

Citation

Barth, R, et al. "Purified Chick Embryo Cell (PCEC) Rabies Vaccine for Human Use. Laboratory Data." Behring Institute Mitteilungen, 1984, pp. 142-54.
Barth R, Gruschkau H, Jaeger O, et al. Purified chick embryo cell (PCEC) rabies vaccine for human use. Laboratory data. Behring Inst Mitt. 1984.
Barth, R., Gruschkau, H., Jaeger, O., Milcke, L., & Weinmann, E. (1984). Purified chick embryo cell (PCEC) rabies vaccine for human use. Laboratory data. Behring Institute Mitteilungen, (76), 142-54.
Barth R, et al. Purified Chick Embryo Cell (PCEC) Rabies Vaccine for Human Use. Laboratory Data. Behring Inst Mitt. 1984;(76)142-54. PubMed PMID: 6525146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Purified chick embryo cell (PCEC) rabies vaccine for human use. Laboratory data. AU - Barth,R, AU - Gruschkau,H, AU - Jaeger,O, AU - Milcke,L, AU - Weinmann,E, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 142 EP - 54 JF - Behring Institute Mitteilungen JO - Behring Inst Mitt IS - 76 N2 - A new inactivated rabies vaccine (Purified Chick Embryo Cell vaccine) for use in humans has been developed. The FLURY-LEP C25 strain of rabies virus was adapted to propagate in primary chick embryo cell cultures. The antigen was purified and concentrated by continuous density gradient centrifugation and inactivated by Betapropiolactone. The PCEC-rabies vaccine was tested for innocuity, tolerability and protective capacity in a series of laboratory tests and compared with Human Diploid Cell Strain rabies vaccine (HDCSV) of similar antigenicity. The results of the laboratory tests indicated that this new vaccine was excellently tolerated and that its protective activity met the high standard of HDCS-vaccine, conditions which were imposed on the PCEC-vaccine before clinical trials in man were initiated. SN - 0301-0457 UR - https://www.unboundmedicine.com/medline/citation/6525146/Purified_chick_embryo_cell__PCEC__rabies_vaccine_for_human_use__Laboratory_data_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -