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Influence of continuous subcutaneous insulin infusion (CSII) treatment on diabetic somatic and autonomic neuropathy.
J Endocrinol Invest. 1984 Dec; 7(6):623-8.JE

Abstract

Near-normal plasma daily glucose profile was induced by Continuous Subcutaneous Insulin Infusion (CSII) treatment in order to evaluate its influence on diabetic somatic and autonomic neuropathy. Twelve insulin-dependent diabetic subjects with somatic neuropathy were studied before and after a short term CSII treatment of 10 days. Four out of these subjects, all affected by autonomic neuropathy, were followed for 1 yr with controls every four months. Metabolic equilibrium was monitored by mean daily plasma glucose (MPDG) profile and by Glycosylated Hemoglobin (GHb) evaluation. Somatic neuropathy was studied assessing conduction velocity at peroneal motor (PMCV) nerve, ulnar motor (UMCV), ulnar sensory (USCV) and sural sensory (SSCV) nerves. Autonomic neuropathy was assessed by means of a battery of five cardiovascular autonomic tests: Valsalva Manoeuvre (VR), Deep Breathing (DB), Lying-to-Standing (LS), Sustained HandGrip (SHG) and Postural Hypotension (PH). Short-term CSII treatment induced a near normalization of metabolic parameters, a significant improvement in VR (p less than 0.05) and DB (p less than 0.01) values, but no changes in NCV. The prolongation of CSII treatment in 4 subjects induced a significant (p less than 0.05) improvement in VR, DB and LS values and in PMCV and UMCV after 4 months. This improvement did not increase with the longer CSII treatment (1 yr).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6530514

Citation

Fedele, D, et al. "Influence of Continuous Subcutaneous Insulin Infusion (CSII) Treatment On Diabetic Somatic and Autonomic Neuropathy." Journal of Endocrinological Investigation, vol. 7, no. 6, 1984, pp. 623-8.
Fedele D, Negrin P, Cardone C, et al. Influence of continuous subcutaneous insulin infusion (CSII) treatment on diabetic somatic and autonomic neuropathy. J Endocrinol Invest. 1984;7(6):623-8.
Fedele, D., Negrin, P., Cardone, C., Bellavere, F., Ferri, M., Briani, G., Nosadini, R., & Crepaldi, G. (1984). Influence of continuous subcutaneous insulin infusion (CSII) treatment on diabetic somatic and autonomic neuropathy. Journal of Endocrinological Investigation, 7(6), 623-8.
Fedele D, et al. Influence of Continuous Subcutaneous Insulin Infusion (CSII) Treatment On Diabetic Somatic and Autonomic Neuropathy. J Endocrinol Invest. 1984;7(6):623-8. PubMed PMID: 6530514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of continuous subcutaneous insulin infusion (CSII) treatment on diabetic somatic and autonomic neuropathy. AU - Fedele,D, AU - Negrin,P, AU - Cardone,C, AU - Bellavere,F, AU - Ferri,M, AU - Briani,G, AU - Nosadini,R, AU - Crepaldi,G, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 623 EP - 8 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 7 IS - 6 N2 - Near-normal plasma daily glucose profile was induced by Continuous Subcutaneous Insulin Infusion (CSII) treatment in order to evaluate its influence on diabetic somatic and autonomic neuropathy. Twelve insulin-dependent diabetic subjects with somatic neuropathy were studied before and after a short term CSII treatment of 10 days. Four out of these subjects, all affected by autonomic neuropathy, were followed for 1 yr with controls every four months. Metabolic equilibrium was monitored by mean daily plasma glucose (MPDG) profile and by Glycosylated Hemoglobin (GHb) evaluation. Somatic neuropathy was studied assessing conduction velocity at peroneal motor (PMCV) nerve, ulnar motor (UMCV), ulnar sensory (USCV) and sural sensory (SSCV) nerves. Autonomic neuropathy was assessed by means of a battery of five cardiovascular autonomic tests: Valsalva Manoeuvre (VR), Deep Breathing (DB), Lying-to-Standing (LS), Sustained HandGrip (SHG) and Postural Hypotension (PH). Short-term CSII treatment induced a near normalization of metabolic parameters, a significant improvement in VR (p less than 0.05) and DB (p less than 0.01) values, but no changes in NCV. The prolongation of CSII treatment in 4 subjects induced a significant (p less than 0.05) improvement in VR, DB and LS values and in PMCV and UMCV after 4 months. This improvement did not increase with the longer CSII treatment (1 yr).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/6530514/Influence_of_continuous_subcutaneous_insulin_infusion__CSII__treatment_on_diabetic_somatic_and_autonomic_neuropathy_ L2 - https://link.springer.com/article/10.1007/BF03349496 DB - PRIME DP - Unbound Medicine ER -