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The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure.
Arch Toxicol. 1984 Dec; 56(2):106-8.AT

Abstract

Tissue carbon monoxide (CO) content was investigated in rats severely intoxicated with CO under various exposure conditions: 1% CO for 4 min, 0.4% CO for 40 min and 0.12% CO for 12 h. Extravascular CO was determined in the heart and skeletal muscles immediately after termination of exposure, and carboxymyoglobin (MbCO) percent saturation was calculated. Total brain CO was estimated immediately after termination of exposure and after the time periods of restitution. After the same exposure conditions, MbCO percent saturation was higher in the heart than in skeletal muscle. In both types of muscle, saturation of myoglobin (Mb) with CO depended on blood carboxyhemoglobin (HbCO) level and not on the duration of exposure. The time course of CO elimination was the same for blood and brain, irrespective of CO exposure conditions. The results obtained showed that acute CO intoxication induced by long duration exposures did not involve CO accumulation in the tissues.

Authors

Sokal JA
No affiliation info available
Majka J
No affiliation info available
Palus J
No affiliation info available

MeSH

AnimalsBrainCarbon MonoxideCarbon Monoxide PoisoningCarboxyhemoglobinFemaleMusclesMyocardiumMyoglobinRatsRats, Inbred StrainsTissue Distribution

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6532373

Citation

Sokal, J A., et al. "The Content of Carbon Monoxide in the Tissues of Rats Intoxicated With Carbon Monoxide in Various Conditions of Acute Exposure." Archives of Toxicology, vol. 56, no. 2, 1984, pp. 106-8.
Sokal JA, Majka J, Palus J. The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure. Arch Toxicol. 1984;56(2):106-8.
Sokal, J. A., Majka, J., & Palus, J. (1984). The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure. Archives of Toxicology, 56(2), 106-8.
Sokal JA, Majka J, Palus J. The Content of Carbon Monoxide in the Tissues of Rats Intoxicated With Carbon Monoxide in Various Conditions of Acute Exposure. Arch Toxicol. 1984;56(2):106-8. PubMed PMID: 6532373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure. AU - Sokal,J A, AU - Majka,J, AU - Palus,J, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 106 EP - 8 JF - Archives of toxicology JO - Arch Toxicol VL - 56 IS - 2 N2 - Tissue carbon monoxide (CO) content was investigated in rats severely intoxicated with CO under various exposure conditions: 1% CO for 4 min, 0.4% CO for 40 min and 0.12% CO for 12 h. Extravascular CO was determined in the heart and skeletal muscles immediately after termination of exposure, and carboxymyoglobin (MbCO) percent saturation was calculated. Total brain CO was estimated immediately after termination of exposure and after the time periods of restitution. After the same exposure conditions, MbCO percent saturation was higher in the heart than in skeletal muscle. In both types of muscle, saturation of myoglobin (Mb) with CO depended on blood carboxyhemoglobin (HbCO) level and not on the duration of exposure. The time course of CO elimination was the same for blood and brain, irrespective of CO exposure conditions. The results obtained showed that acute CO intoxication induced by long duration exposures did not involve CO accumulation in the tissues. SN - 0340-5761 UR - https://www.unboundmedicine.com/medline/citation/6532373/The_content_of_carbon_monoxide_in_the_tissues_of_rats_intoxicated_with_carbon_monoxide_in_various_conditions_of_acute_exposure_ L2 - https://doi.org/10.1007/BF00349080 DB - PRIME DP - Unbound Medicine ER -