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Functional evaluation of the adenohypophysis with metoclopramide in hyperprolactinemic-amenorrheic women in relation to radiological findings on the sella turcica.
Endocrinol Jpn. 1984 Dec; 31(6):733-9.EJ

Abstract

The responses of the adenohypophyseal hormones to metoclopramide (MCP) were evaluated in hyperprolactinemic women with various radiological findings on the sella turcica. Serum PRL concentrations significantly increased after MCP administration in normal women, hyperprolactinemic patients with normal sella and patients with microadenoma, but not in macroadenoma patients with and without suprasellar expansion (SSE). The PRL response to MCP administration was significantly lower in hyperprolactinemic patients than in normal women. Serum TSH concentrations significantly increased after MCP administration in each group of subjects. The TSH response to MCP was significantly higher in patients with normal sella and patients with microadenoma than in normal women. However, the responses of PRL and TSH to MCP were not significantly different between patients with normal sella and patients with microadenoma. Therefore, they were not considered useful in distinguishing tumorous from nontumorous hyperprolactinemia. Serum LH concentrations significantly increased after MCP administration in patients with normal sella, patients with microadenoma and macroadenoma patients without SSE, but not in normal women or macroadenoma patients with SSE. The LH response to MCP was significantly higher in patients with microadenoma than in patients with normal sella. Serum FSH concentrations significantly increased after MCP administration only in patients with microadenoma. The different responses of the adenohypophyseal hormones to MCP in hyperprolactinemic women with various radiological findings on the sella turcica may be explained by the difference in the hypothalamic dopamine activity and in the impairment of the hypothalamic-pituitary system due to pituitary tumor.

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6532792

Citation

Seki, K, et al. "Functional Evaluation of the Adenohypophysis With Metoclopramide in Hyperprolactinemic-amenorrheic Women in Relation to Radiological Findings On the Sella Turcica." Endocrinologia Japonica, vol. 31, no. 6, 1984, pp. 733-9.
Seki K, Uesato T, Kato K, et al. Functional evaluation of the adenohypophysis with metoclopramide in hyperprolactinemic-amenorrheic women in relation to radiological findings on the sella turcica. Endocrinol Jpn. 1984;31(6):733-9.
Seki, K., Uesato, T., Kato, K., & Shima, K. (1984). Functional evaluation of the adenohypophysis with metoclopramide in hyperprolactinemic-amenorrheic women in relation to radiological findings on the sella turcica. Endocrinologia Japonica, 31(6), 733-9.
Seki K, et al. Functional Evaluation of the Adenohypophysis With Metoclopramide in Hyperprolactinemic-amenorrheic Women in Relation to Radiological Findings On the Sella Turcica. Endocrinol Jpn. 1984;31(6):733-9. PubMed PMID: 6532792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional evaluation of the adenohypophysis with metoclopramide in hyperprolactinemic-amenorrheic women in relation to radiological findings on the sella turcica. AU - Seki,K, AU - Uesato,T, AU - Kato,K, AU - Shima,K, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 733 EP - 9 JF - Endocrinologia japonica JO - Endocrinol Jpn VL - 31 IS - 6 N2 - The responses of the adenohypophyseal hormones to metoclopramide (MCP) were evaluated in hyperprolactinemic women with various radiological findings on the sella turcica. Serum PRL concentrations significantly increased after MCP administration in normal women, hyperprolactinemic patients with normal sella and patients with microadenoma, but not in macroadenoma patients with and without suprasellar expansion (SSE). The PRL response to MCP administration was significantly lower in hyperprolactinemic patients than in normal women. Serum TSH concentrations significantly increased after MCP administration in each group of subjects. The TSH response to MCP was significantly higher in patients with normal sella and patients with microadenoma than in normal women. However, the responses of PRL and TSH to MCP were not significantly different between patients with normal sella and patients with microadenoma. Therefore, they were not considered useful in distinguishing tumorous from nontumorous hyperprolactinemia. Serum LH concentrations significantly increased after MCP administration in patients with normal sella, patients with microadenoma and macroadenoma patients without SSE, but not in normal women or macroadenoma patients with SSE. The LH response to MCP was significantly higher in patients with microadenoma than in patients with normal sella. Serum FSH concentrations significantly increased after MCP administration only in patients with microadenoma. The different responses of the adenohypophyseal hormones to MCP in hyperprolactinemic women with various radiological findings on the sella turcica may be explained by the difference in the hypothalamic dopamine activity and in the impairment of the hypothalamic-pituitary system due to pituitary tumor. SN - 0013-7219 UR - https://www.unboundmedicine.com/medline/citation/6532792/Functional_evaluation_of_the_adenohypophysis_with_metoclopramide_in_hyperprolactinemic_amenorrheic_women_in_relation_to_radiological_findings_on_the_sella_turcica_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1954/31.733?from=PubMed DB - PRIME DP - Unbound Medicine ER -