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Diet and serum sex hormones in healthy men.

Abstract

The possible effect of dietary fat content and the ratio of polyunsaturated to saturated fatty acids (P/S-ratio) on serum sex hormones was studied in 30 healthy male volunteers. The customary diet of the subjects, which supplied 40% of energy as fat (mainly from animal sources, P/S-ratio 0.15) was replaced for a 6 weeks period by a practically isocaloric experimental diet containing significantly less fat (25% of energy) with a higher P/S-ratio (1.22) and other environmental factors were stabilized. Serum testosterone and 4-androstenedione decreased from 22.7 +/- 1.1 nmol/l to 19.3 +/- 1.2 nmol/l, (SEM, P less than 0.001) and from 4.6 +/- 0.2 nmol/l to 4.3 +/- 0.2 nmol/l (SEM, P less than 0.01), respectively. These changes were paralleled by a reduction in serum free (non-protein bound) testosterone (P less than 0.01) suggesting a possible change in biological activity. During the low fat period a significant negative correlation between serum prolactin and androgens was observed. All the changes in androgen levels were reversible. With the exception of a small but non-significant decrease in serum estradiol-17 beta, the other hormone parameters were practically unaffected by the dietary manipulation. Our results indicate that in men a decrease in dietary fat content and an increase in the degree of unsaturation of fatty acids reduces the serum concentrations of androstenedione, testosterone and free testosterone. The mechanism and importance of this phenomenon is discussed in the light of epidemiological and experimental data.

Authors

, , ,

Source

Journal of steroid biochemistry 20:1 1984 Jan pg 459-64

MeSH

Adult
Androstenedione
Diet
Dietary Fats
Energy Intake
Estradiol
Gonadal Steroid Hormones
Humans
Male
Middle Aged
Sex Hormone-Binding Globulin
Testosterone

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6538617

Citation

Hämäläinen, E, et al. "Diet and Serum Sex Hormones in Healthy Men." Journal of Steroid Biochemistry, vol. 20, no. 1, 1984, pp. 459-64.
Hämäläinen E, Adlercreutz H, Puska P, et al. Diet and serum sex hormones in healthy men. J Steroid Biochem. 1984;20(1):459-64.
Hämäläinen, E., Adlercreutz, H., Puska, P., & Pietinen, P. (1984). Diet and serum sex hormones in healthy men. Journal of Steroid Biochemistry, 20(1), pp. 459-64.
Hämäläinen E, et al. Diet and Serum Sex Hormones in Healthy Men. J Steroid Biochem. 1984;20(1):459-64. PubMed PMID: 6538617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and serum sex hormones in healthy men. AU - Hämäläinen,E, AU - Adlercreutz,H, AU - Puska,P, AU - Pietinen,P, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 459 EP - 64 JF - Journal of steroid biochemistry JO - J. Steroid Biochem. VL - 20 IS - 1 N2 - The possible effect of dietary fat content and the ratio of polyunsaturated to saturated fatty acids (P/S-ratio) on serum sex hormones was studied in 30 healthy male volunteers. The customary diet of the subjects, which supplied 40% of energy as fat (mainly from animal sources, P/S-ratio 0.15) was replaced for a 6 weeks period by a practically isocaloric experimental diet containing significantly less fat (25% of energy) with a higher P/S-ratio (1.22) and other environmental factors were stabilized. Serum testosterone and 4-androstenedione decreased from 22.7 +/- 1.1 nmol/l to 19.3 +/- 1.2 nmol/l, (SEM, P less than 0.001) and from 4.6 +/- 0.2 nmol/l to 4.3 +/- 0.2 nmol/l (SEM, P less than 0.01), respectively. These changes were paralleled by a reduction in serum free (non-protein bound) testosterone (P less than 0.01) suggesting a possible change in biological activity. During the low fat period a significant negative correlation between serum prolactin and androgens was observed. All the changes in androgen levels were reversible. With the exception of a small but non-significant decrease in serum estradiol-17 beta, the other hormone parameters were practically unaffected by the dietary manipulation. Our results indicate that in men a decrease in dietary fat content and an increase in the degree of unsaturation of fatty acids reduces the serum concentrations of androstenedione, testosterone and free testosterone. The mechanism and importance of this phenomenon is discussed in the light of epidemiological and experimental data. SN - 0022-4731 UR - https://www.unboundmedicine.com/medline/citation/6538617/full_citation DB - PRIME DP - Unbound Medicine ER -