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Eustachian tube obstruction after provocative nasal antigen challenge.
Arch Otolaryngol. 1984 Aug; 110(8):508-11.AO

Abstract

To test if allergic rhinitis is associated with abnormal eustachian tube function (ET), juvenile rhesus monkeys were passively sensitized with serum samples from patients allergic to timothy grass or ragweed pollen. Tympanostomy tubes were inserted for direct measurement of ET function by inflation-deflation and forced-response testing before and after provocative intranasal challenge. Intranasal challenge with pollen (antigen) resulted in rhinorrhea and nasal obstruction. Slight increases in passive ET function values and significantly impaired active ET function were observed after antigen challenge. No changes in nasal airway patency or active ET function resulted from control nonantigen pollen challenges. These data complement our studies in man and support the use of this model to evaluate the relationships among allergic rhinitis, ET function and middle ear disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6540079

Citation

Doyle, W J., et al. "Eustachian Tube Obstruction After Provocative Nasal Antigen Challenge." Archives of Otolaryngology (Chicago, Ill. : 1960), vol. 110, no. 8, 1984, pp. 508-11.
Doyle WJ, Friedman R, Fireman P, et al. Eustachian tube obstruction after provocative nasal antigen challenge. Arch Otolaryngol. 1984;110(8):508-11.
Doyle, W. J., Friedman, R., Fireman, P., & Bluestone, C. D. (1984). Eustachian tube obstruction after provocative nasal antigen challenge. Archives of Otolaryngology (Chicago, Ill. : 1960), 110(8), 508-11.
Doyle WJ, et al. Eustachian Tube Obstruction After Provocative Nasal Antigen Challenge. Arch Otolaryngol. 1984;110(8):508-11. PubMed PMID: 6540079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eustachian tube obstruction after provocative nasal antigen challenge. AU - Doyle,W J, AU - Friedman,R, AU - Fireman,P, AU - Bluestone,C D, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 508 EP - 11 JF - Archives of otolaryngology (Chicago, Ill. : 1960) JO - Arch Otolaryngol VL - 110 IS - 8 N2 - To test if allergic rhinitis is associated with abnormal eustachian tube function (ET), juvenile rhesus monkeys were passively sensitized with serum samples from patients allergic to timothy grass or ragweed pollen. Tympanostomy tubes were inserted for direct measurement of ET function by inflation-deflation and forced-response testing before and after provocative intranasal challenge. Intranasal challenge with pollen (antigen) resulted in rhinorrhea and nasal obstruction. Slight increases in passive ET function values and significantly impaired active ET function were observed after antigen challenge. No changes in nasal airway patency or active ET function resulted from control nonantigen pollen challenges. These data complement our studies in man and support the use of this model to evaluate the relationships among allergic rhinitis, ET function and middle ear disease. SN - 0003-9977 UR - https://www.unboundmedicine.com/medline/citation/6540079/Eustachian_tube_obstruction_after_provocative_nasal_antigen_challenge_ L2 - https://medlineplus.gov/hayfever.html DB - PRIME DP - Unbound Medicine ER -