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Iron pharmacokinetics after administration of ferric-hydroxide-polymaltose complex in rats.
Arzneimittelforschung. 1984; 34(11):1560-9.A

Abstract

This paper reports a study of the pharmacokinetics of ferrous sulphate and ferric-hydroxide-polymaltose complex (Hw 6400, Ferrum Hausmann) administered orally and intravenously to anaemic and non-anaemic rats of both sexes. Radiolabelled ferrous sulphate and ferric-hydroxide-polymaltose complex was used to study iron utilization after oral administration. Measurements of radioactivity in serum, packed red cells, whole blood, liver, kidney, spleen, bone and in some cases in the gastrointestinal tract were made following a range of dosages between 0.84 and 41.9 mg Fe/kg. No significant difference in bioavailability or iron utilization was found between the two iron preparations. Pharmacokinetic measurements following i.v. administration showed different distribution volumes, iron clearance and elimination constants for the two preparations. This difference in pharmacokinetic behaviour following oral administration, particularly in the case of non-anaemic rats, was confirmed by the observation that a 10- to 20 fold smaller dose of FeSO4 than of iron-polymaltose complex was required to achieve the same rise in serum iron. It is therefore not justifiable to draw conclusions about the bioavailability of chemically different iron preparations (iron salts and iron hydroxide complexes) on the basis of AUC values for serum iron increases observed in non-anaemic animals or human subjects.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6543131

Citation

Geisser, P, and A Müller. "Iron Pharmacokinetics After Administration of Ferric-hydroxide-polymaltose Complex in Rats." Arzneimittel-Forschung, vol. 34, no. 11, 1984, pp. 1560-9.
Geisser P, Müller A. Iron pharmacokinetics after administration of ferric-hydroxide-polymaltose complex in rats. Arzneimittelforschung. 1984;34(11):1560-9.
Geisser, P., & Müller, A. (1984). Iron pharmacokinetics after administration of ferric-hydroxide-polymaltose complex in rats. Arzneimittel-Forschung, 34(11), 1560-9.
Geisser P, Müller A. Iron Pharmacokinetics After Administration of Ferric-hydroxide-polymaltose Complex in Rats. Arzneimittelforschung. 1984;34(11):1560-9. PubMed PMID: 6543131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron pharmacokinetics after administration of ferric-hydroxide-polymaltose complex in rats. AU - Geisser,P, AU - Müller,A, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 1560 EP - 9 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 34 IS - 11 N2 - This paper reports a study of the pharmacokinetics of ferrous sulphate and ferric-hydroxide-polymaltose complex (Hw 6400, Ferrum Hausmann) administered orally and intravenously to anaemic and non-anaemic rats of both sexes. Radiolabelled ferrous sulphate and ferric-hydroxide-polymaltose complex was used to study iron utilization after oral administration. Measurements of radioactivity in serum, packed red cells, whole blood, liver, kidney, spleen, bone and in some cases in the gastrointestinal tract were made following a range of dosages between 0.84 and 41.9 mg Fe/kg. No significant difference in bioavailability or iron utilization was found between the two iron preparations. Pharmacokinetic measurements following i.v. administration showed different distribution volumes, iron clearance and elimination constants for the two preparations. This difference in pharmacokinetic behaviour following oral administration, particularly in the case of non-anaemic rats, was confirmed by the observation that a 10- to 20 fold smaller dose of FeSO4 than of iron-polymaltose complex was required to achieve the same rise in serum iron. It is therefore not justifiable to draw conclusions about the bioavailability of chemically different iron preparations (iron salts and iron hydroxide complexes) on the basis of AUC values for serum iron increases observed in non-anaemic animals or human subjects. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/6543131/Iron_pharmacokinetics_after_administration_of_ferric_hydroxide_polymaltose_complex_in_rats_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -