Tags

Type your tag names separated by a space and hit enter

The diagnosis of iron deficiency by erythrocyte protoporphyrin and serum ferritin analyses.
Acta Paediatr Scand. 1978 May; 67(3):361-6.AP

Abstract

Free erythrocyte protoporphyrin (FEP) and serum ferritin have been determined in 57 healthy children and in 25 children with varying degrees of iron deficiency. FEP was found to be inversely correlated to the concentration of hemoglobin (r = -0.80) as well as to serum ferritin (r=-0.64). Elevated FEP was found in children with hemoglobin less than 12.5 g/dl, or serum ferritin less than 8 microgram/l. In a group of apparently hematologically normal children between the age of 10--14 years (hemoglobin greater than 12.5 g/dl), a 2-month-trial of iron medication resulted in an increase in hemoglobin and ferritin, and a decrease in FEP, indicating suboptimal supply of iron for hemoglobin synthesis before iron medication. In a patient with iron deficiency (FEP 15.3 mumole/l, hemoglobin 5.2 g/dl), iron therapy was followed by a rapid fall in FEP before any changes in hemoglobin, serum iron transferrin saturation and ferritin could be detected. The rapid fall in FEP during start of treatment in iron deficiency makes FEP a sensitive biochemical parameter on iron homeostasis in iron deficiency anemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

654913

Citation

Koller, M E., et al. "The Diagnosis of Iron Deficiency By Erythrocyte Protoporphyrin and Serum Ferritin Analyses." Acta Paediatrica Scandinavica, vol. 67, no. 3, 1978, pp. 361-6.
Koller ME, Romslo I, Finne PH, et al. The diagnosis of iron deficiency by erythrocyte protoporphyrin and serum ferritin analyses. Acta Paediatr Scand. 1978;67(3):361-6.
Koller, M. E., Romslo, I., Finne, P. H., Brockmeier, F., & Tyssebotn, I. (1978). The diagnosis of iron deficiency by erythrocyte protoporphyrin and serum ferritin analyses. Acta Paediatrica Scandinavica, 67(3), 361-6.
Koller ME, et al. The Diagnosis of Iron Deficiency By Erythrocyte Protoporphyrin and Serum Ferritin Analyses. Acta Paediatr Scand. 1978;67(3):361-6. PubMed PMID: 654913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnosis of iron deficiency by erythrocyte protoporphyrin and serum ferritin analyses. AU - Koller,M E, AU - Romslo,I, AU - Finne,P H, AU - Brockmeier,F, AU - Tyssebotn,I, PY - 1978/5/1/pubmed PY - 1978/5/1/medline PY - 1978/5/1/entrez SP - 361 EP - 6 JF - Acta paediatrica Scandinavica JO - Acta Paediatr Scand VL - 67 IS - 3 N2 - Free erythrocyte protoporphyrin (FEP) and serum ferritin have been determined in 57 healthy children and in 25 children with varying degrees of iron deficiency. FEP was found to be inversely correlated to the concentration of hemoglobin (r = -0.80) as well as to serum ferritin (r=-0.64). Elevated FEP was found in children with hemoglobin less than 12.5 g/dl, or serum ferritin less than 8 microgram/l. In a group of apparently hematologically normal children between the age of 10--14 years (hemoglobin greater than 12.5 g/dl), a 2-month-trial of iron medication resulted in an increase in hemoglobin and ferritin, and a decrease in FEP, indicating suboptimal supply of iron for hemoglobin synthesis before iron medication. In a patient with iron deficiency (FEP 15.3 mumole/l, hemoglobin 5.2 g/dl), iron therapy was followed by a rapid fall in FEP before any changes in hemoglobin, serum iron transferrin saturation and ferritin could be detected. The rapid fall in FEP during start of treatment in iron deficiency makes FEP a sensitive biochemical parameter on iron homeostasis in iron deficiency anemia. SN - 0001-656X UR - https://www.unboundmedicine.com/medline/citation/654913/The_diagnosis_of_iron_deficiency_by_erythrocyte_protoporphyrin_and_serum_ferritin_analyses_ DB - PRIME DP - Unbound Medicine ER -