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Enhanced elimination of warfarin during treatment with cholestyramine.
Br J Clin Pharmacol. 1978 May; 5(5):437-40.BJ

Abstract

1 The elimination and anticoagulant activity of a single intravenous dose of warfarin (1.0-1.2 mg/kg) without and with concomitant cholestyramine treatment (about 4 g three times daily) was studied in five healthy male subjects. 2 Cholestyramine treatment decreased the biological half-life of plasma warfarin (from a mean value of 2 days -1.3 days) and increased the total clearance of this drug (from a mean value of 37 ml kg-1 day-1--53 ml kg--1 day--1). 3 The total anticoagulant effect per dose of warfarin, as measured by the area under the effect v time curve, was also reduced by cholestyramine (average reduction of about 25%). 4 Warfarin possibly undergoes enterohepatic recycling in man which can be interrupted by cholestyramine.

Authors

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Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

656283

Citation

Jähnchen, E, et al. "Enhanced Elimination of Warfarin During Treatment With Cholestyramine." British Journal of Clinical Pharmacology, vol. 5, no. 5, 1978, pp. 437-40.
Jähnchen E, Meinertz T, Gilfrich HJ, et al. Enhanced elimination of warfarin during treatment with cholestyramine. Br J Clin Pharmacol. 1978;5(5):437-40.
Jähnchen, E., Meinertz, T., Gilfrich, H. J., Kersting, F., & Groth, U. (1978). Enhanced elimination of warfarin during treatment with cholestyramine. British Journal of Clinical Pharmacology, 5(5), 437-40.
Jähnchen E, et al. Enhanced Elimination of Warfarin During Treatment With Cholestyramine. Br J Clin Pharmacol. 1978;5(5):437-40. PubMed PMID: 656283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced elimination of warfarin during treatment with cholestyramine. AU - Jähnchen,E, AU - Meinertz,T, AU - Gilfrich,H J, AU - Kersting,F, AU - Groth,U, PY - 1978/5/1/pubmed PY - 1978/5/1/medline PY - 1978/5/1/entrez SP - 437 EP - 40 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 5 IS - 5 N2 - 1 The elimination and anticoagulant activity of a single intravenous dose of warfarin (1.0-1.2 mg/kg) without and with concomitant cholestyramine treatment (about 4 g three times daily) was studied in five healthy male subjects. 2 Cholestyramine treatment decreased the biological half-life of plasma warfarin (from a mean value of 2 days -1.3 days) and increased the total clearance of this drug (from a mean value of 37 ml kg-1 day-1--53 ml kg--1 day--1). 3 The total anticoagulant effect per dose of warfarin, as measured by the area under the effect v time curve, was also reduced by cholestyramine (average reduction of about 25%). 4 Warfarin possibly undergoes enterohepatic recycling in man which can be interrupted by cholestyramine. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/656283/Enhanced_elimination_of_warfarin_during_treatment_with_cholestyramine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1978&volume=5&issue=5&spage=437 DB - PRIME DP - Unbound Medicine ER -