TY - JOUR T1 - Enhanced elimination of warfarin during treatment with cholestyramine. AU - Jähnchen,E, AU - Meinertz,T, AU - Gilfrich,H J, AU - Kersting,F, AU - Groth,U, PY - 1978/5/1/pubmed PY - 1978/5/1/medline PY - 1978/5/1/entrez SP - 437 EP - 40 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 5 IS - 5 N2 - 1 The elimination and anticoagulant activity of a single intravenous dose of warfarin (1.0-1.2 mg/kg) without and with concomitant cholestyramine treatment (about 4 g three times daily) was studied in five healthy male subjects. 2 Cholestyramine treatment decreased the biological half-life of plasma warfarin (from a mean value of 2 days -1.3 days) and increased the total clearance of this drug (from a mean value of 37 ml kg-1 day-1--53 ml kg--1 day--1). 3 The total anticoagulant effect per dose of warfarin, as measured by the area under the effect v time curve, was also reduced by cholestyramine (average reduction of about 25%). 4 Warfarin possibly undergoes enterohepatic recycling in man which can be interrupted by cholestyramine. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/656283/Enhanced_elimination_of_warfarin_during_treatment_with_cholestyramine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1978&volume=5&issue=5&spage=437 DB - PRIME DP - Unbound Medicine ER -