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[Serotonin precursors as antidepressive agents: a review].
Fortschr Neurol Psychiatr 1983; 51(5):176-82FN

Abstract

The serotonin hypothesis postulates a decreased function of this neurotransmitter in the central nervous system of depressed patients. L-tryptophan and--more specific--5-hydroxytryptophan are natural precursors of this biogenic amine. Results of numerous therapeutic trials with L-tryptophan are not convincing of this compound's antidepressant efficacy in marked to severe endogenous depressions. On the other hand, it cannot be excluded that it is effective in moderate dysphoric states with apathy and sleep disturbances. However, possible toxic effects of high and long term use render its clinical use doubtful. The antidepressant efficacy of 5-hydroxytryptophan has not been proven. However, the possibility exists that a serotonin deficient subgroup of depressed patients responds to this substance and further, that it has depression prophylactic properties. As both tryptophan and 5-hydroxytryptophan are less effective than tricyclic antidepressants and not without side effects they do not appear to be useful antidepressants.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6603403

Citation

Beckmann, H, and S Kasper. "[Serotonin Precursors as Antidepressive Agents: a Review]." Fortschritte Der Neurologie-Psychiatrie, vol. 51, no. 5, 1983, pp. 176-82.
Beckmann H, Kasper S. [Serotonin precursors as antidepressive agents: a review]. Fortschr Neurol Psychiatr. 1983;51(5):176-82.
Beckmann, H., & Kasper, S. (1983). [Serotonin precursors as antidepressive agents: a review]. Fortschritte Der Neurologie-Psychiatrie, 51(5), pp. 176-82.
Beckmann H, Kasper S. [Serotonin Precursors as Antidepressive Agents: a Review]. Fortschr Neurol Psychiatr. 1983;51(5):176-82. PubMed PMID: 6603403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serotonin precursors as antidepressive agents: a review]. AU - Beckmann,H, AU - Kasper,S, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 176 EP - 82 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 51 IS - 5 N2 - The serotonin hypothesis postulates a decreased function of this neurotransmitter in the central nervous system of depressed patients. L-tryptophan and--more specific--5-hydroxytryptophan are natural precursors of this biogenic amine. Results of numerous therapeutic trials with L-tryptophan are not convincing of this compound's antidepressant efficacy in marked to severe endogenous depressions. On the other hand, it cannot be excluded that it is effective in moderate dysphoric states with apathy and sleep disturbances. However, possible toxic effects of high and long term use render its clinical use doubtful. The antidepressant efficacy of 5-hydroxytryptophan has not been proven. However, the possibility exists that a serotonin deficient subgroup of depressed patients responds to this substance and further, that it has depression prophylactic properties. As both tryptophan and 5-hydroxytryptophan are less effective than tricyclic antidepressants and not without side effects they do not appear to be useful antidepressants. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/6603403/[Serotonin_precursors_as_antidepressive_agents:_a_review]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1002225 DB - PRIME DP - Unbound Medicine ER -