Tags

Type your tag names separated by a space and hit enter

Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein.
J Lab Clin Med 1983; 102(4):470-6JL

Abstract

Controversy persists regarding the abnormality of bone turnover responsible for bone loss in women with postmenopausal osteoporosis. To evaluate this, we measured serum bone Gla-protein (BGP), a specific marker for bone turnover, in 62 untreated patients with postmenopausal osteoporosis. Results were compared with those in 142 normal women and were expressed as standard deviations from the age-adjusted predicted mean (Z score). Serum BGP was increased (+0.48 S.D., p = 0.002) in the osteoporotic patients; 9.7% of patients were greater than 2 S.D. above but none were greater than 2 S.D. below the normal mean. Moreover, when data from normal postmenopausal women (ages 51 to 75 years) and the osteoporotic patients were merged, significant negative correlation existed (r = -0.36, p less than 0.001) between serum BGP and bone density of the lumbar spine assessed by dual photon absorptiometry. Serum alkaline phosphatase, a less specific marker for bone formation, was also increased (+0.96 S.D., p less than 0.001) in the osteoporotic patients. The data suggest that overall bone turnover is increased in patients with postmenopausal osteoporosis and do not support the concept that an absolute decrease in bone formation is the major cause of the bone loss.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6604769

Citation

Delmas, P D., et al. "Assessment of Bone Turnover in Postmenopausal Osteoporosis By Measurement of Serum Bone Gla-protein." The Journal of Laboratory and Clinical Medicine, vol. 102, no. 4, 1983, pp. 470-6.
Delmas PD, Wahner HW, Mann KG, et al. Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein. J Lab Clin Med. 1983;102(4):470-6.
Delmas, P. D., Wahner, H. W., Mann, K. G., & Riggs, B. L. (1983). Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein. The Journal of Laboratory and Clinical Medicine, 102(4), pp. 470-6.
Delmas PD, et al. Assessment of Bone Turnover in Postmenopausal Osteoporosis By Measurement of Serum Bone Gla-protein. J Lab Clin Med. 1983;102(4):470-6. PubMed PMID: 6604769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein. AU - Delmas,P D, AU - Wahner,H W, AU - Mann,K G, AU - Riggs,B L, PY - 1983/10/1/pubmed PY - 1983/10/1/medline PY - 1983/10/1/entrez SP - 470 EP - 6 JF - The Journal of laboratory and clinical medicine JO - J. Lab. Clin. Med. VL - 102 IS - 4 N2 - Controversy persists regarding the abnormality of bone turnover responsible for bone loss in women with postmenopausal osteoporosis. To evaluate this, we measured serum bone Gla-protein (BGP), a specific marker for bone turnover, in 62 untreated patients with postmenopausal osteoporosis. Results were compared with those in 142 normal women and were expressed as standard deviations from the age-adjusted predicted mean (Z score). Serum BGP was increased (+0.48 S.D., p = 0.002) in the osteoporotic patients; 9.7% of patients were greater than 2 S.D. above but none were greater than 2 S.D. below the normal mean. Moreover, when data from normal postmenopausal women (ages 51 to 75 years) and the osteoporotic patients were merged, significant negative correlation existed (r = -0.36, p less than 0.001) between serum BGP and bone density of the lumbar spine assessed by dual photon absorptiometry. Serum alkaline phosphatase, a less specific marker for bone formation, was also increased (+0.96 S.D., p less than 0.001) in the osteoporotic patients. The data suggest that overall bone turnover is increased in patients with postmenopausal osteoporosis and do not support the concept that an absolute decrease in bone formation is the major cause of the bone loss. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/6604769/Assessment_of_bone_turnover_in_postmenopausal_osteoporosis_by_measurement_of_serum_bone_Gla_protein_ L2 - http://www.diseaseinfosearch.org/result/9059 DB - PRIME DP - Unbound Medicine ER -