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Androgen stimulated elevation in androgen receptor levels is inhibited by the synthetic glucocorticoid triamcinolone acetonide.
Biochem Biophys Res Commun. 1983 Nov 15; 116(3):1020-5.BB

Abstract

Two cloned tumor cell lines derived from the rat prostate and hamster ductus deferens contain receptors for androgens and glucocorticoids. Androgens increase both the rate of proliferation in these cells and induce a doubling in the number of androgen receptors within 6 hours. This elevation in androgen receptors is dependent on protein synthesis. The glucocorticoid triamcinolone acetonide specifically inhibits both these androgen mediated events without altering the equilibrium dissociation constant (Kd) of the androgen receptor for either [3H]-methyltrienolone (Kd = 0.46 nM) or [3H]-dihydrotestosterone (Kd = 0.2 nM). These observations infer that androgen receptor up-regulation is an important facet of androgen action which may be modulated by glucocorticoids.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6606427

Citation

Syms, A J., et al. "Androgen Stimulated Elevation in Androgen Receptor Levels Is Inhibited By the Synthetic Glucocorticoid Triamcinolone Acetonide." Biochemical and Biophysical Research Communications, vol. 116, no. 3, 1983, pp. 1020-5.
Syms AJ, Norris JS, Smith RG. Androgen stimulated elevation in androgen receptor levels is inhibited by the synthetic glucocorticoid triamcinolone acetonide. Biochem Biophys Res Commun. 1983;116(3):1020-5.
Syms, A. J., Norris, J. S., & Smith, R. G. (1983). Androgen stimulated elevation in androgen receptor levels is inhibited by the synthetic glucocorticoid triamcinolone acetonide. Biochemical and Biophysical Research Communications, 116(3), 1020-5.
Syms AJ, Norris JS, Smith RG. Androgen Stimulated Elevation in Androgen Receptor Levels Is Inhibited By the Synthetic Glucocorticoid Triamcinolone Acetonide. Biochem Biophys Res Commun. 1983 Nov 15;116(3):1020-5. PubMed PMID: 6606427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgen stimulated elevation in androgen receptor levels is inhibited by the synthetic glucocorticoid triamcinolone acetonide. AU - Syms,A J, AU - Norris,J S, AU - Smith,R G, PY - 1983/11/15/pubmed PY - 1983/11/15/medline PY - 1983/11/15/entrez SP - 1020 EP - 5 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 116 IS - 3 N2 - Two cloned tumor cell lines derived from the rat prostate and hamster ductus deferens contain receptors for androgens and glucocorticoids. Androgens increase both the rate of proliferation in these cells and induce a doubling in the number of androgen receptors within 6 hours. This elevation in androgen receptors is dependent on protein synthesis. The glucocorticoid triamcinolone acetonide specifically inhibits both these androgen mediated events without altering the equilibrium dissociation constant (Kd) of the androgen receptor for either [3H]-methyltrienolone (Kd = 0.46 nM) or [3H]-dihydrotestosterone (Kd = 0.2 nM). These observations infer that androgen receptor up-regulation is an important facet of androgen action which may be modulated by glucocorticoids. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/6606427/Androgen_stimulated_elevation_in_androgen_receptor_levels_is_inhibited_by_the_synthetic_glucocorticoid_triamcinolone_acetonide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(83)80244-7 DB - PRIME DP - Unbound Medicine ER -