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Correlation between serial pulmonary function tests and fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome.
Am Rev Respir Dis. 1984 Mar; 129(3):491-3.AR

Abstract

The records of 9 adult male patients with the acquired immune deficiency syndrome (AIDS) and biopsy-proved Pneumocystis carinii pneumonia were reviewed to determine the correlation between serial pulmonary function tests and the presence or absence of Pneumocystis organisms in subsequent bronchoscopy specimens. At diagnosis, total lung capacity (TLC) or vital capacity (VC) was abnormally low in 4 patients (44%) and diffusing capacity (DLCO) was abnormally low in 8 patients (89%). The ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) was elevated in all patients. After 21 to 47 days of specific therapy for Pneumocystis pneumonia, changes in DLCO, TLC, VC, and FEV1/FVC did not correlate with the presence or absence of Pneumocystis organisms in bronchoscopy specimens from 7 patients. However, changes in DLCO 105 to 258 days after diagnosis seemed to correlate with the late response to treatment in 6 patients. These results suggest that decisions to terminate specific therapy for Pneumocystis pneumonia in patients with AIDS should not be based on short-term changes in pulmonary function.

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Authors

Coleman DL
No affiliation info available
Dodek PM
No affiliation info available
Golden JA
No affiliation info available
Luce JM
No affiliation info available
Golden E
No affiliation info available
Gold WM
No affiliation info available
Murray JF
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeBronchoscopyFiber Optic TechnologyFollow-Up StudiesHumansMalePneumonia, PneumocystisRespiratory Function TestsTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6608299

Citation

Coleman, D L., et al. "Correlation Between Serial Pulmonary Function Tests and Fiberoptic Bronchoscopy in Patients With Pneumocystis Carinii Pneumonia and the Acquired Immune Deficiency Syndrome." The American Review of Respiratory Disease, vol. 129, no. 3, 1984, pp. 491-3.
Coleman DL, Dodek PM, Golden JA, et al. Correlation between serial pulmonary function tests and fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. Am Rev Respir Dis. 1984;129(3):491-3.
Coleman, D. L., Dodek, P. M., Golden, J. A., Luce, J. M., Golden, E., Gold, W. M., & Murray, J. F. (1984). Correlation between serial pulmonary function tests and fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. The American Review of Respiratory Disease, 129(3), 491-3.
Coleman DL, et al. Correlation Between Serial Pulmonary Function Tests and Fiberoptic Bronchoscopy in Patients With Pneumocystis Carinii Pneumonia and the Acquired Immune Deficiency Syndrome. Am Rev Respir Dis. 1984;129(3):491-3. PubMed PMID: 6608299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between serial pulmonary function tests and fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. AU - Coleman,D L, AU - Dodek,P M, AU - Golden,J A, AU - Luce,J M, AU - Golden,E, AU - Gold,W M, AU - Murray,J F, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 491 EP - 3 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 129 IS - 3 N2 - The records of 9 adult male patients with the acquired immune deficiency syndrome (AIDS) and biopsy-proved Pneumocystis carinii pneumonia were reviewed to determine the correlation between serial pulmonary function tests and the presence or absence of Pneumocystis organisms in subsequent bronchoscopy specimens. At diagnosis, total lung capacity (TLC) or vital capacity (VC) was abnormally low in 4 patients (44%) and diffusing capacity (DLCO) was abnormally low in 8 patients (89%). The ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) was elevated in all patients. After 21 to 47 days of specific therapy for Pneumocystis pneumonia, changes in DLCO, TLC, VC, and FEV1/FVC did not correlate with the presence or absence of Pneumocystis organisms in bronchoscopy specimens from 7 patients. However, changes in DLCO 105 to 258 days after diagnosis seemed to correlate with the late response to treatment in 6 patients. These results suggest that decisions to terminate specific therapy for Pneumocystis pneumonia in patients with AIDS should not be based on short-term changes in pulmonary function. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/6608299/Correlation_between_serial_pulmonary_function_tests_and_fiberoptic_bronchoscopy_in_patients_with_Pneumocystis_carinii_pneumonia_and_the_acquired_immune_deficiency_syndrome_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1984.129.3.491?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -