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Increased frequency of HLA-A1 and -B8 in association with total lack, but not with deficiency of serum IgA.
Tissue Antigens 1984; 23(5):280-3TA

Abstract

HLA-A, B, C typing was performed on 37 unrelated healthy blood donors with selective deficiency (less than 0.05 g/l) or total lack (less than 0.00002 g/l) of serum IgA. A significant increase in HLA-B8 and A1 antigen frequency was found in the 15 individuals with lack of serum IgA. This was not observed among those 22, who had only deficiency of serum IgA (0.00002-0.05 g/l). The HLA antigen frequencies were compared to those of 900 randomly selected healthy blood donors. Increased frequency of HLA-A1 and B8 in association with total lack of serum IgA, but not with deficiency has not been demonstrated before. On the basis of this result it seems conceivable that lack of serum IgA may be caused by a different, perhaps genetically determined, mechanism than IgA deficiency.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6611606

Citation

Heikkilä, M, et al. "Increased Frequency of HLA-A1 and -B8 in Association With Total Lack, but Not With Deficiency of Serum IgA." Tissue Antigens, vol. 23, no. 5, 1984, pp. 280-3.
Heikkilä M, Koistinen J, Lohman M, et al. Increased frequency of HLA-A1 and -B8 in association with total lack, but not with deficiency of serum IgA. Tissue Antigens. 1984;23(5):280-3.
Heikkilä, M., Koistinen, J., Lohman, M., & Koskimies, S. (1984). Increased frequency of HLA-A1 and -B8 in association with total lack, but not with deficiency of serum IgA. Tissue Antigens, 23(5), pp. 280-3.
Heikkilä M, et al. Increased Frequency of HLA-A1 and -B8 in Association With Total Lack, but Not With Deficiency of Serum IgA. Tissue Antigens. 1984;23(5):280-3. PubMed PMID: 6611606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased frequency of HLA-A1 and -B8 in association with total lack, but not with deficiency of serum IgA. AU - Heikkilä,M, AU - Koistinen,J, AU - Lohman,M, AU - Koskimies,S, PY - 1984/5/1/pubmed PY - 1984/5/1/medline PY - 1984/5/1/entrez SP - 280 EP - 3 JF - Tissue antigens JO - Tissue Antigens VL - 23 IS - 5 N2 - HLA-A, B, C typing was performed on 37 unrelated healthy blood donors with selective deficiency (less than 0.05 g/l) or total lack (less than 0.00002 g/l) of serum IgA. A significant increase in HLA-B8 and A1 antigen frequency was found in the 15 individuals with lack of serum IgA. This was not observed among those 22, who had only deficiency of serum IgA (0.00002-0.05 g/l). The HLA antigen frequencies were compared to those of 900 randomly selected healthy blood donors. Increased frequency of HLA-A1 and B8 in association with total lack of serum IgA, but not with deficiency has not been demonstrated before. On the basis of this result it seems conceivable that lack of serum IgA may be caused by a different, perhaps genetically determined, mechanism than IgA deficiency. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/6611606/Increased_frequency_of_HLA_A1_and__B8_in_association_with_total_lack_but_not_with_deficiency_of_serum_IgA_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=1984&volume=23&issue=5&spage=280 DB - PRIME DP - Unbound Medicine ER -