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Effects of alpha-trichosanthin and alpha-momorcharin on the development of peri-implantation mouse embryos.
J Reprod Fertil. 1983 Nov; 69(2):597-604.JR

Abstract

alpha-Trichosanthin (0.3 mg/25 g) and alpha-momorcharin (0.2 mg/25 g) given intraperitoneally to mice on Days 4 and 6 of pregnancy led to an inhibition of implantation. In-vitro study of the effects of these proteins on developing mouse embryos showed that these proteins did not affect the transformation of morulae to blastocysts but further development was impaired: many blastocysts failed to hatch from the zona, the incidence of successful attachment to a plastic substrate decreased and the extent of trophoblastic outgrowth diminished. Inner cell mass development was less affected than was the trophoblast. The in-vivo inhibition of implantation may therefore be a consequence of the deleterious effect of these proteins on the trophoblast.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6631823

Citation

Law, L K., et al. "Effects of Alpha-trichosanthin and Alpha-momorcharin On the Development of Peri-implantation Mouse Embryos." Journal of Reproduction and Fertility, vol. 69, no. 2, 1983, pp. 597-604.
Law LK, Tam PP, Yeung HW. Effects of alpha-trichosanthin and alpha-momorcharin on the development of peri-implantation mouse embryos. J Reprod Fertil. 1983;69(2):597-604.
Law, L. K., Tam, P. P., & Yeung, H. W. (1983). Effects of alpha-trichosanthin and alpha-momorcharin on the development of peri-implantation mouse embryos. Journal of Reproduction and Fertility, 69(2), 597-604.
Law LK, Tam PP, Yeung HW. Effects of Alpha-trichosanthin and Alpha-momorcharin On the Development of Peri-implantation Mouse Embryos. J Reprod Fertil. 1983;69(2):597-604. PubMed PMID: 6631823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alpha-trichosanthin and alpha-momorcharin on the development of peri-implantation mouse embryos. AU - Law,L K, AU - Tam,P P, AU - Yeung,H W, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 597 EP - 604 JF - Journal of reproduction and fertility JO - J Reprod Fertil VL - 69 IS - 2 N2 - alpha-Trichosanthin (0.3 mg/25 g) and alpha-momorcharin (0.2 mg/25 g) given intraperitoneally to mice on Days 4 and 6 of pregnancy led to an inhibition of implantation. In-vitro study of the effects of these proteins on developing mouse embryos showed that these proteins did not affect the transformation of morulae to blastocysts but further development was impaired: many blastocysts failed to hatch from the zona, the incidence of successful attachment to a plastic substrate decreased and the extent of trophoblastic outgrowth diminished. Inner cell mass development was less affected than was the trophoblast. The in-vivo inhibition of implantation may therefore be a consequence of the deleterious effect of these proteins on the trophoblast. SN - 0022-4251 UR - https://www.unboundmedicine.com/medline/citation/6631823/Effects_of_alpha_trichosanthin_and_alpha_momorcharin_on_the_development_of_peri_implantation_mouse_embryos_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6631823 DB - PRIME DP - Unbound Medicine ER -