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Serum T3 and reverse T3 levels in hepatic cirrhosis: relation to hepatocellular damage and normalization on improvement in liver dysfunction.
Am J Gastroenterol. 1983 Nov; 78(11):750-5.AJ

Abstract

Liver is one of the major sites of T4 metabolism. Several studies have reported low serum T3 concentrations and elevated reverse T3 (rT3) levels in hepatic cirrhosis. This study examined the influence of degree of the hepatocellular damage and the effect of improvement in clinical state on thyroid hormone concentrations in 44 cirrhotic patients. Low serum T4 and T3 as well as raised rT3 were observed in cirrhotic patients with advanced liver dysfunction alone. T3 resin uptake was increased in some of these patients suggesting decrease in serum thyroid-binding globulin concentration. In patients with histological changes but with normal liver function tests, serum T4, T3, and rT3 were not altered. Serum T3 and rT3 correlated significantly with liver function tests. T4, T3, and rT3 normalized on improvement in clinical status and liver function tests. Lowest levels of T4 and T3 with extremely high rT3 were seen in patients with extremely advanced liver dysfunction. In these patients, the mortality was high. Therefore, in hepatic cirrhosis, 1) T4 metabolism is altered with lowering of T4 and T3 and a rise in rT3. 2) These changes may be dependent on the degree of hepatocellular damage and reverse on improvement in liver function. 3) T4, T3, and rT3 levels are useful prognostic indices.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6637968

Citation

Kabadi, U M., and B N. Premachandra. "Serum T3 and Reverse T3 Levels in Hepatic Cirrhosis: Relation to Hepatocellular Damage and Normalization On Improvement in Liver Dysfunction." The American Journal of Gastroenterology, vol. 78, no. 11, 1983, pp. 750-5.
Kabadi UM, Premachandra BN. Serum T3 and reverse T3 levels in hepatic cirrhosis: relation to hepatocellular damage and normalization on improvement in liver dysfunction. Am J Gastroenterol. 1983;78(11):750-5.
Kabadi, U. M., & Premachandra, B. N. (1983). Serum T3 and reverse T3 levels in hepatic cirrhosis: relation to hepatocellular damage and normalization on improvement in liver dysfunction. The American Journal of Gastroenterology, 78(11), 750-5.
Kabadi UM, Premachandra BN. Serum T3 and Reverse T3 Levels in Hepatic Cirrhosis: Relation to Hepatocellular Damage and Normalization On Improvement in Liver Dysfunction. Am J Gastroenterol. 1983;78(11):750-5. PubMed PMID: 6637968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum T3 and reverse T3 levels in hepatic cirrhosis: relation to hepatocellular damage and normalization on improvement in liver dysfunction. AU - Kabadi,U M, AU - Premachandra,B N, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 750 EP - 5 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 78 IS - 11 N2 - Liver is one of the major sites of T4 metabolism. Several studies have reported low serum T3 concentrations and elevated reverse T3 (rT3) levels in hepatic cirrhosis. This study examined the influence of degree of the hepatocellular damage and the effect of improvement in clinical state on thyroid hormone concentrations in 44 cirrhotic patients. Low serum T4 and T3 as well as raised rT3 were observed in cirrhotic patients with advanced liver dysfunction alone. T3 resin uptake was increased in some of these patients suggesting decrease in serum thyroid-binding globulin concentration. In patients with histological changes but with normal liver function tests, serum T4, T3, and rT3 were not altered. Serum T3 and rT3 correlated significantly with liver function tests. T4, T3, and rT3 normalized on improvement in clinical status and liver function tests. Lowest levels of T4 and T3 with extremely high rT3 were seen in patients with extremely advanced liver dysfunction. In these patients, the mortality was high. Therefore, in hepatic cirrhosis, 1) T4 metabolism is altered with lowering of T4 and T3 and a rise in rT3. 2) These changes may be dependent on the degree of hepatocellular damage and reverse on improvement in liver function. 3) T4, T3, and rT3 levels are useful prognostic indices. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/6637968/Serum_T3_and_reverse_T3_levels_in_hepatic_cirrhosis:_relation_to_hepatocellular_damage_and_normalization_on_improvement_in_liver_dysfunction_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -