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The effect of water deprivation on local renal blood flow and filtration in the laboratory rat.
Circ Shock. 1983; 11(2):175-86.CS

Abstract

The effects of longlasting dehydration on total and local renal blood flow and glomerular filtration rate have not been studied previously in the laboratory rat. We therefore determined zonal renal blood flow (ZRBF) in cortical and medullary zones by the 125I-iodoantipyrine and H2 gas washout techniques. After 8 days of water deprivation renal blood flow (RBF) was reduced by 65% and renal vascular resistance (RVR) had increased by 110%. Half the RVR increase could be ascribed to increased blood viscosity as reflected by increased hematocrit (42 to 60%). Fractional ZRBF decreased by 5% in the outer half and increased by 5% in the inner half of the cortex. Measurements of the relative single nephron glomerular filtration rate (sngfr) of superficial and deep nephrons, determined by the 14C-ferrocyanide technique, indicated no detectable changes in filtrate distribution. Both ZRBF and sngfr heterogeneity had increased in dehydrated as compared to control rats. In one rat studied with the H2 gas washout method, local ischemia and intermittent blood flow occurred. Similarly, cortical patches of nonfiltering nephrons were observed in another rat. These findings suggest that the increased heterogeneity of intrarenal flow and filtration may involve, and in part be due to, intermittent local changes in blood flow.

Authors

Hope A
No affiliation info available
Tyssebotn I
No affiliation info available

MeSH

AnimalsAntipyrineBlood PressureBlood ProteinsBody WeightFemaleGlomerular Filtration RateHematocritHemoglobinsKidney CortexKidney MedullaMaleRatsRats, Inbred StrainsRenal CirculationVascular ResistanceWater Deprivation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6640859

Citation

Hope, A, and I Tyssebotn. "The Effect of Water Deprivation On Local Renal Blood Flow and Filtration in the Laboratory Rat." Circulatory Shock, vol. 11, no. 2, 1983, pp. 175-86.
Hope A, Tyssebotn I. The effect of water deprivation on local renal blood flow and filtration in the laboratory rat. Circ Shock. 1983;11(2):175-86.
Hope, A., & Tyssebotn, I. (1983). The effect of water deprivation on local renal blood flow and filtration in the laboratory rat. Circulatory Shock, 11(2), 175-86.
Hope A, Tyssebotn I. The Effect of Water Deprivation On Local Renal Blood Flow and Filtration in the Laboratory Rat. Circ Shock. 1983;11(2):175-86. PubMed PMID: 6640859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of water deprivation on local renal blood flow and filtration in the laboratory rat. AU - Hope,A, AU - Tyssebotn,I, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 175 EP - 86 JF - Circulatory shock JO - Circ Shock VL - 11 IS - 2 N2 - The effects of longlasting dehydration on total and local renal blood flow and glomerular filtration rate have not been studied previously in the laboratory rat. We therefore determined zonal renal blood flow (ZRBF) in cortical and medullary zones by the 125I-iodoantipyrine and H2 gas washout techniques. After 8 days of water deprivation renal blood flow (RBF) was reduced by 65% and renal vascular resistance (RVR) had increased by 110%. Half the RVR increase could be ascribed to increased blood viscosity as reflected by increased hematocrit (42 to 60%). Fractional ZRBF decreased by 5% in the outer half and increased by 5% in the inner half of the cortex. Measurements of the relative single nephron glomerular filtration rate (sngfr) of superficial and deep nephrons, determined by the 14C-ferrocyanide technique, indicated no detectable changes in filtrate distribution. Both ZRBF and sngfr heterogeneity had increased in dehydrated as compared to control rats. In one rat studied with the H2 gas washout method, local ischemia and intermittent blood flow occurred. Similarly, cortical patches of nonfiltering nephrons were observed in another rat. These findings suggest that the increased heterogeneity of intrarenal flow and filtration may involve, and in part be due to, intermittent local changes in blood flow. SN - 0092-6213 UR - https://www.unboundmedicine.com/medline/citation/6640859/The_effect_of_water_deprivation_on_local_renal_blood_flow_and_filtration_in_the_laboratory_rat_ DB - PRIME DP - Unbound Medicine ER -