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The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids.
J Neural Transm. 1983; 57(3):187-95.JN

Abstract

We measured plasma concentrations of tryptophan (Trp) and the other large neutral amino acids (LNAA) in 6 control and 7 obese subjects before and after they consumed a low-carbohydrate "protein-sparing modified fast" (PSMF) diet; LNAA levels in control subjects were also assessed after supplemental oral Trp. Consumption of the PSMF diet by non-obese subjects, or obesity per se, caused major reductions in the ratio of the plasma Trp concentration to the summed plasma concentrations of the other LNAA (i.e., the "plasma Trp ratio"), and may thus have diminished brain serotonin synthesis. Administration of even 2 g of supplemental Trp did not elevate the plasma Trp ratio beyond the normal range observed previously in subjects consuming carbohydrate-containing meals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6644285

Citation

Heraief, E, et al. "The Treatment of Obesity By Carbohydrate Deprivation Suppresses Plasma Tryptophan and Its Ratio to Other Large Neutral Amino Acids." Journal of Neural Transmission, vol. 57, no. 3, 1983, pp. 187-95.
Heraief E, Burckhardt P, Mauron C, et al. The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids. J Neural Transm. 1983;57(3):187-95.
Heraief, E., Burckhardt, P., Mauron, C., Wurtman, J. J., & Wurtman, R. J. (1983). The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids. Journal of Neural Transmission, 57(3), 187-95.
Heraief E, et al. The Treatment of Obesity By Carbohydrate Deprivation Suppresses Plasma Tryptophan and Its Ratio to Other Large Neutral Amino Acids. J Neural Transm. 1983;57(3):187-95. PubMed PMID: 6644285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids. AU - Heraief,E, AU - Burckhardt,P, AU - Mauron,C, AU - Wurtman,J J, AU - Wurtman,R J, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 187 EP - 95 JF - Journal of neural transmission JO - J Neural Transm VL - 57 IS - 3 N2 - We measured plasma concentrations of tryptophan (Trp) and the other large neutral amino acids (LNAA) in 6 control and 7 obese subjects before and after they consumed a low-carbohydrate "protein-sparing modified fast" (PSMF) diet; LNAA levels in control subjects were also assessed after supplemental oral Trp. Consumption of the PSMF diet by non-obese subjects, or obesity per se, caused major reductions in the ratio of the plasma Trp concentration to the summed plasma concentrations of the other LNAA (i.e., the "plasma Trp ratio"), and may thus have diminished brain serotonin synthesis. Administration of even 2 g of supplemental Trp did not elevate the plasma Trp ratio beyond the normal range observed previously in subjects consuming carbohydrate-containing meals. UR - https://www.unboundmedicine.com/medline/citation/6644285/The_treatment_of_obesity_by_carbohydrate_deprivation_suppresses_plasma_tryptophan_and_its_ratio_to_other_large_neutral_amino_acids_ L2 - https://doi.org/10.1007/BF01245117 DB - PRIME DP - Unbound Medicine ER -