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Effects of acrylamide on locomotion and central monoamine function in the rat.
Pharmacol Biochem Behav 1983; 19(4):635-44PB

Abstract

Male rats receiving acrylamide (ACR) in their drinking water (100 ppm) for a six-week period displayed increased psychomotor stimulation to d-amphetamine (d-A; 1.0 mg/kg SC) under several conditions of handling and drug administration. Following behavioral tests a subset of the animals was sacrificed at 15, 50, 80 and 120 minutes following d-A and the brains removed and dissected for determinations of regional brain levels of several monoamine neurotransmitters and metabolites. ACR rats had elevated levels of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum, septal area, and thalamus. The effect was most pronounced at 15 minutes post-drug with ACR rats not demonstrating a depression in 5-HIAA levels present in controls. Increases in accumben's dopamine and norepinephrine levels, evident after d-A, were of lesser magnitude in ACR-exposed rats. Decreases in dihydroxyphenylacetic acid and homovanillic acid, also evident after d-A, persisted for a longer duration in ACR-exposed rats. Light and electron microscopy of spinal cord, striatum, nucleus accumbens and thalamus did not reveal morphologic abnormalities. Sciatic nerves showed histopathological changes characteristic of multi-focal dying-back peripheral nerve degeneration. It was concluded that acrylamide's effect on the psychomotor stimulant properties of d-A may be related to changes in a serotonergic inhibitory system.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6647502

Citation

Rafales, L S., et al. "Effects of Acrylamide On Locomotion and Central Monoamine Function in the Rat." Pharmacology, Biochemistry, and Behavior, vol. 19, no. 4, 1983, pp. 635-44.
Rafales LS, Lasley SM, Greenland RD, et al. Effects of acrylamide on locomotion and central monoamine function in the rat. Pharmacol Biochem Behav. 1983;19(4):635-44.
Rafales, L. S., Lasley, S. M., Greenland, R. D., & Mandybur, T. (1983). Effects of acrylamide on locomotion and central monoamine function in the rat. Pharmacology, Biochemistry, and Behavior, 19(4), pp. 635-44.
Rafales LS, et al. Effects of Acrylamide On Locomotion and Central Monoamine Function in the Rat. Pharmacol Biochem Behav. 1983;19(4):635-44. PubMed PMID: 6647502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acrylamide on locomotion and central monoamine function in the rat. AU - Rafales,L S, AU - Lasley,S M, AU - Greenland,R D, AU - Mandybur,T, PY - 1983/10/1/pubmed PY - 1983/10/1/medline PY - 1983/10/1/entrez SP - 635 EP - 44 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 19 IS - 4 N2 - Male rats receiving acrylamide (ACR) in their drinking water (100 ppm) for a six-week period displayed increased psychomotor stimulation to d-amphetamine (d-A; 1.0 mg/kg SC) under several conditions of handling and drug administration. Following behavioral tests a subset of the animals was sacrificed at 15, 50, 80 and 120 minutes following d-A and the brains removed and dissected for determinations of regional brain levels of several monoamine neurotransmitters and metabolites. ACR rats had elevated levels of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum, septal area, and thalamus. The effect was most pronounced at 15 minutes post-drug with ACR rats not demonstrating a depression in 5-HIAA levels present in controls. Increases in accumben's dopamine and norepinephrine levels, evident after d-A, were of lesser magnitude in ACR-exposed rats. Decreases in dihydroxyphenylacetic acid and homovanillic acid, also evident after d-A, persisted for a longer duration in ACR-exposed rats. Light and electron microscopy of spinal cord, striatum, nucleus accumbens and thalamus did not reveal morphologic abnormalities. Sciatic nerves showed histopathological changes characteristic of multi-focal dying-back peripheral nerve degeneration. It was concluded that acrylamide's effect on the psychomotor stimulant properties of d-A may be related to changes in a serotonergic inhibitory system. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/6647502/Effects_of_acrylamide_on_locomotion_and_central_monoamine_function_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(83)90339-8 DB - PRIME DP - Unbound Medicine ER -